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Cat. No.: HY-162535

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GSPT1 degrader-6

GSPT1 degrader-6 is a GSPT1 molecular glue degrader that recruits cereblon (CRBN), with a DC₅₀ of 13 nM. GSPT1 degrader-6 induces GSPT1 protein degradation via the ubiquitin-proteasome pathway. GSPT1 degrader-6 can be used in breast cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 3034764-41-2
Formula: C₂₄H₂₂ClN₅O₅
Molecular Weight:495.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

GSPT1 degrader-6 Chemical Structure

CAS No.: 3034764-41-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

eRF3a/GSPT1

13 nM (DC₅₀)

All Eukaryotic Release Factor (eRF) Isoforms :

In Vitro

GSPT1 degrader-6 (compound 8) (6 h) induces concentration-dependent degradation of GSPT1 protein in CAL51 breast cancer cells, with a DC₅₀ of 13 nM and a maximum degradation rate of 94.6%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3034764-41-2
Molecular Weight 495.91
Formula C₂₄H₂₂ClN₅O₅
SMILES

ClC1=CC(NC(OCC2=CC=C3C(C=C(CN4C5C(NC(CC5)=O)=O)N3C4=O)=C2)=O)=CC=C1NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jinghai, Jin, et al. Fused ring compound, pharmaceutical composition, and use thereof. Patent. WO2024067792A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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