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Cat. No.: HY-189901

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HBV CAM-1

Name: HBV CAM-1
Brand: MedChemExpress
SKU: HY-189901
Availability: PreOrder

(Synonyms: HBV capsid assembly modulator-1)

HBV CAM-1 is an HBV capsid protein modulator with a K_d of 48.6 μM. HBV CAM-1 inhibits HBV DNA. HBV CAM-1 can be used in research on hepatitis B virus (HBV) infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₀H₂₁F₂N₃O₃S
Masse moléculaire:421.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HBV CAM-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

HBV CAM-1 is an HBV capsid protein modulator with a K_d of 48.6 μM. HBV CAM-1 inhibits HBV DNA. HBV CAM-1 can be used in research on hepatitis B virus (HBV) infection^[1].

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	10 μM	Cytotoxicity against human HepG2 cells assessed as viability reduction with CC50 greater than 10 μM by MTS assay after 4 days incubation. Cytotoxicity against human HepG2 cells assessed as viability reduction with CC50 greater than 10 μM by MTS assay after 4 days incubation.	Integrated-AI-Driven-Multi-Objective-Optimization

In Vitro

Viral InfectionOthers

Viral Infection

HBV CAM-1 (Compound 11B-6) binds HBV Cp monomer with a K_D of 48.6 μM in SPR^[1].
HBV CAM-1 (3 days) inhibits HBV DNA replication in HepAD38 cells with an EC₅₀ of 0.04 μM^[1].

Others

HBV CAM-1 (2 μM; approximately 16 h) exhibits 84.3% plasma protein binding in plasma in equilibrium dialysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

HepAD38 cells; HepG2 cells
Concentration:

Various concentrations (HepAD38; initial assay and 9-point dose-response); 40 or 20 mM DMSO stocks
Incubation Time:

3 days (9-point qPCR); 4 days (HepG2 cytotoxicity)
Result:

In HepAD38 cells, HBV DNA replication was inhibited with EC₅₀ = 0.04 μM, CC₅₀ >10 μM, and SI >250.

Related Protocols :

Research Protocol for Infectious Diseases

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	MRT_0-t	MRT_0-∞	F	V_z	CL
Rat^[1]	2 mg/kg	i.v.	6.13 h	0.0833 h	1527 ng/mL	812 ng·h/mL	1013 ng·h/mL	1.50 h	4.62 h	/	17,429 mL/kg	2006 mL/h/kg
Rat^[1]	10 mg/kg	p.o.	6.53 h	0.500 h	8.64 ng/mL	21.6 ng·h/mL	40.8 ng·h/mL	2.77 h	9.43 h	0.83 %	/	/

Chemical Information

Masse moléculaire 421.46
Formule C₂₀H₂₁F₂N₃O₃S
SMILES

O=C(NC1=CC=C(F)C(C)=C1)C2=CC=C(F)C(S(=O)(NC[C@@H]3[C@@]4([H])CNC[C@@]34[H])=O)=C2
Synonyms

HBV capsid assembly modulator-1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang S, et al. Integrated AI-Driven Multi-Objective Optimization of Sulfamoylbenzamide-Based HBV Capsid Assembly Modulators: Discovery of 11B-6 with Superior Potency and Drug-like Properties[J]. Journal of Medicinal Chemistry, 2026, 69(19): 22539-22564.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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HBV CAM-1

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis