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Cat. No.: HY-146008

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hCAII-IN-3

hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 403.8, 5.1, 10.2 and 5.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-2 shows anticancer activity.

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CAS No.: 2770927-76-7
화학식: C₁₇H₂₁N₃O₃S
분자량:347.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

hCAII-IN-3 Chemical Structure

CAS No.: 2770927-76-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

CA XII

CA Ⅱ

CA IX

All Carbonic Anhydrase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	29.3 μM Compound: 16	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay	[PMID: 35551035]
MCF7	IC₅₀	5.7 μM Compound: 16	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay	[PMID: 35551035]
T47D	IC₅₀	10.9 μM Compound: 16	Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay	[PMID: 35551035]
T47D	IC₅₀	43.1 μM Compound: 16	Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay	[PMID: 35551035]

Chemical Information

CAS No. 2770927-76-7
분자량 347.43
화학식 C₁₇H₂₁N₃O₃S
SMILES

NS(=O)(C1=CC=C(C=C1)NCC/C(C2=CC=CC=C2)=N/CCO)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elbadawi MM, et al. Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Apr 27;238:114412. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

hCAII-IN-3

All Carbonic Anhydrase Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

hCAII-IN-3 Related Classifications

HY-146008 Related Classifications

Bioz

Keywords

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