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製品番号: HY-146008

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hCAII-IN-3

hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 403.8, 5.1, 10.2 and 5.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-2 shows anticancer activity.

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CAS 番号: 2770927-76-7
分子式: C₁₇H₂₁N₃O₃S
分子量:347.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

hCAII-IN-3 構造式

CAS 番号: 2770927-76-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

CA XII

CA Ⅱ

CA IX

Carbonic Anhydrase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	29.3 μM Compound: 16	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay	[PMID: 35551035]
MCF7	IC₅₀	5.7 μM Compound: 16	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay	[PMID: 35551035]
T47D	IC₅₀	10.9 μM Compound: 16	Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under hypoxia condition by MTT colorimetric assay	[PMID: 35551035]
T47D	IC₅₀	43.1 μM Compound: 16	Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 4 hrs under normoxia condition by MTT colorimetric assay	[PMID: 35551035]

化学情報

CAS 番号 2770927-76-7
分子量 347.43
分子式 C₁₇H₂₁N₃O₃S
SMILES

NS(=O)(C1=CC=C(C=C1)NCC/C(C2=CC=CC=C2)=N/CCO)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Elbadawi MM, et al. Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Apr 27;238:114412. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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hCAII-IN-3

Carbonic Anhydrase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

hCAII-IN-3 関連分類

HY-146008 関連分類