Herbicidal agent 16 

Herbicidal agent 16 is a herbicide and Protoporphyrinogen IX oxidase (PPO) inhibitor with an IC₅₀ of 15.1 nM and K_d of 24.89 nM. Herbicidal agent 16 can be used for research on herbicides^[1].

Herbicidal agent 16 (Compound S1) (4.69-150 g a.i./ha; 7 days post-treatment) provides 80-100% postemergence control of Echinochloa crus-galli, Digitaria sanguinalis, Setaria viridis, Amaranthus retroflexus, Abutilon theophrasti, and Veronica polita at concentrations as low as 4.69 g a.i./ha^[1].
Herbicidal agent 16 (37.5-150 g a.i./ha) exhibits broad-spectrum herbicidal activity, providing 80-100% control of 24 diverse weed species at 150 g a.i./ha^[1].
Herbicidal agent 16 (37.5-150 g a.i./ha; 14 days post-treatment) is safe for rice and wheat at dosages up to 150 g a.i./ha, causing only 0-20% phytotoxicity, while exhibiting higher phytotoxicity to corn, soybean, cotton, and peanut^[1].
Herbicidal agent 16 potently inhibits plant PPO enzyme activity with an IC₅₀ of 15.1 nM^[1].
Herbicidal agent 16 (1.57-50.00 nM) binds to purified PPO protein with high affinity, exhibiting a K_d of 24.89 nM^[1].
Herbicidal agent 16 (150 g a.i./ha; 3-24 h post-treatment) rapidly and significantly downregulates relative PPO gene expression in Nicotiana benthamiana leaves, with suppression observed as early as 3 h post-treatment^[1].
Herbicidal agent 16 binds to the active site of PPO enzyme (PDB ID: 1SEZ) via multiple stabilizing interactions, including π-π stacking, halogen bonds, hydrogen bonds, and hydrophobic interactions, contributing to its high inhibitory potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

456.91

C₁₇H₁₇ClF₄N₂O₂S₂

O=C1N(C2=CC(C(SCC)SCC)=C(Cl)C=C2F)C(C=C(C(F)(F)F)N1C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Song C, et al. Design and Synthesis of Novel Pyrimidinedione Derivatives Containing Dithioacetal Structures as Safer Protoporphyrinogen IX Oxidase Inhibitors. J Agric Food Chem. 2026;74(17):13552-13563.  [Content Brief]