HIF-2α-IN-9
HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity.
For research use only. We do not sell to patients.
- CAS No.: 2648334-36-3
- Formula: C12H13F5O4S2
- Molecular Weight:380.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
HIF-2α[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | IC50 |
80 nM
Compound: 35r
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Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
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[PMID: 37403966] |
Chemical Information
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CAS No. 2648334-36-3
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Molecular Weight 380.35
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Formula C12H13F5O4S2
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SMILES
FC1(F)[C@@H](O)C2=C(S(=O)(C)=O)SC(OC[C@H](C)C(F)(F)F)=C2C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIF-2α-IN-9 Related Classifications
HY-149886 Related Classifications
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