HJC0152 free base
Based on 3 publication(s) in Google Scholar
HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice.
For research use only. We do not sell to patients.
- Purity: 98.30%
- CAS No.: 1420290-88-5
- Formula: C15H13Cl2N3O4
- Molecular Weight:370.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HJC0152 free base
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Customer Validation & Images
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WB
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IF
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RT-PCR
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In Vivo Efficacy Study
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Histological Imaging/Staining
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | IC50 |
1.9 μM
Compound: 11, HJC0152
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Cytotoxicity against human AsPC1 cells after 72 hrs by MTS assay
Cytotoxicity against human AsPC1 cells after 72 hrs by MTS assay
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[PMID: 23459613] |
| MCF-10A | IC50 |
6.73 μM
Compound: 2; HJC0152
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Cytotoxicity against human MCF-10A cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| MCF7 | IC50 |
0.91 μM
Compound: 11, HJC0152
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Cytotoxicity against human ER positive MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human ER positive MCF7 cells after 72 hrs by MTS assay
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[PMID: 23459613] |
| MCF7 | IC50 |
4.14 μM
Compound: 2; HJC0152
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| MDA-MB-231 | IC50 |
1.64 μM
Compound: 11, HJC0152
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Cytotoxicity against human ER negative MDA-MB-231 cells after 72 hrs by MTS assay
Cytotoxicity against human ER negative MDA-MB-231 cells after 72 hrs by MTS assay
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[PMID: 23459613] |
| MDA-MB-231 | IC50 |
3.48 μM
Compound: 2; HJC0152
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| MDA-MB-468 | IC50 |
5.05 μM
Compound: 2; HJC0152
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| PANC-1 | IC50 |
1.08 μM
Compound: 11, HJC0152
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Cytotoxicity against human PANC1 cells after 72 hrs by MTS assay
Cytotoxicity against human PANC1 cells after 72 hrs by MTS assay
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[PMID: 23459613] |
| T47D | IC50 |
1.88 μM
Compound: 2; HJC0152
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Antiproliferative activity against human T47D cells assessed as inhibition of cell growth incubated fro 72 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as inhibition of cell growth incubated fro 72 hrs by MTT assay
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[PMID: 35334447] |
Chemical Information
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CAS No. 1420290-88-5
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Appearance Solid
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Molecular Weight 370.19
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Formula C15H13Cl2N3O4
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Color White to off-white
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SMILES
NCCOC1=C(C=C(Cl)C=C1)C(=O)NC2=C(Cl)C=C([N+](=O)[O-])C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
STAT3 Increases CVB3 Replication and Acute Pancreatitis and Myocarditis Pathology via Impeding Nuclear Translocation of STAT1 and Interferon-Stimulated Gene Expression. [Abstract]2024 Aug 19;25(16):9007. PMID: 39201692
HJC0152 free base purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 19;25(16):9007. [Abstract]
Nucleic or cytoplasmic p-STAT1 and STAT1 expressions were analyzed by immunoblotting analysis treated with HJC0152 (10 μM) for 48 h.
HJC0152 free base purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 19;25(16):9007. [Abstract]
IF assay to analyze nuclear translocation of p-STAT1 in STAT3 inhibitor-treated cells. Acinar 266-6 cells were mock-infected or infected with CVB3 and fixed 12 h p.i. The p-STAT1 expression and localizations were analyzed by confocal microscopy treated with HJC0152 (10 μM) for 48 h.
HJC0152 free base purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 19;25(16):9007. [Abstract]
mRNA levels of ISGs (OAS, MXA, ISG15, ISG56, Viperin and CXCL10 and GAPDH) from HJC0152 (10 μM)-treated cells were analyzed by RT-QPCR.
HJC0152 free base purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 19;25(16):9007. [Abstract]
Survival curve and weight loss curve in STAT3 inhibitor (HJC0152) (12.5 mg/kg, i.p.)-treated mice were followed by 7 dpi.
HJC0152 free base purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 19;25(16):9007. [Abstract]
Representative hematoxylin–eosin (H&E)-stained pancreas and heart sections from infected mice treated with HJC0152 (12.5 mg/kg, i.p.).
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Fish Shellfish Immunol
Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages from turbot (Scophthalmus maximus L.). [Abstract]2023 Dec:143:109214. PMID: 37977544 -
Naunyn Schmiedebergs Arch Pharmacol
Corynoline promotes apoptosis and inhibits proliferation of glioblastoma via regulating the STAT3/Bcl-2 signalling pathway. [Abstract]2025 Dec 11. PMID: 41379317
Solvent & Solubility
DMSO : 4.12 mg/mL (11.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7013 mL | 13.5066 mL | 27.0132 mL | 67.5329 mL |
| 5 mM | 0.5403 mL | 2.7013 mL | 5.4026 mL | 13.5066 mL | |
| 10 mM | 0.2701 mL | 1.3507 mL | 2.7013 mL | 6.7533 mL |
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