ICI 216140
Based on 1 Customer Validation
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 124001-41-8
- Formula: C45H65N13O8
- Molecular Weight:916.08
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 124001-41-8
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Appearance Solid
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Molecular Weight 916.08
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Formula C45H65N13O8
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Color White to off-white
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Sequence
{N-Isobutyryl}-His-Trp-Ala-Val-{d-(Ala)}-His-Leu-NHMe
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Sequence Shortening
{N-Isobutyryl}-HWAV-{d-(Ala)}-HL-NHMe
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (54.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Camble R, et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antaconist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 1989;45(17):1521-1527. [Content Brief]
[2]. Zogovic B, et al. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011;301(5):R1486-R1494. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0916 mL | 5.4580 mL | 10.9161 mL | 27.2902 mL |
| 5 mM | 0.2183 mL | 1.0916 mL | 2.1832 mL | 5.4580 mL | |
| 10 mM | 0.1092 mL | 0.5458 mL | 1.0916 mL | 2.7290 mL | |
| 15 mM | 0.0728 mL | 0.3639 mL | 0.7277 mL | 1.8193 mL | |
| 20 mM | 0.0546 mL | 0.2729 mL | 0.5458 mL | 1.3645 mL | |
| 25 mM | 0.0437 mL | 0.2183 mL | 0.4366 mL | 1.0916 mL | |
| 30 mM | 0.0364 mL | 0.1819 mL | 0.3639 mL | 0.9097 mL | |
| 40 mM | 0.0273 mL | 0.1365 mL | 0.2729 mL | 0.6823 mL | |
| 50 mM | 0.0218 mL | 0.1092 mL | 0.2183 mL | 0.5458 mL |
ICI 216140 Related Classifications
HY-P3112 Related Classifications
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