DUSP3 - dual specificity phosphatase 3 Gene

Also Known as VHR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1845

About DUSP3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,766,125-43,778,977 (from NCBI)

This gene has 5 transcripts (splice variants), 90 orthologues and 30 paralogues. Ubiquitous expression in heart (RPKM 57.5), esophagus (RPKM 29.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian Cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast Cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

DUSP3 Products (1)

mRNA Protein Name
NM_004090.4 NP_004081.1 dual specificity protein phosphatase 3

DUSP3 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (37 - 175)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 3

  • dual specificity protein phosphatase VHR

DUSP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DUSP3 P51452 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
DUSP3 P51452 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DUSP3 Proteins

Cat. No. Product Name Accession Purity
HY-P71150 DUSP3 Protein, Human (His) P51452-1 (S2-P185) ≥ 95%, as determined by reducing SDS-PAGE.

DUSP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80646 DUSP3 Antibody WB, IHC-F, IHC-P, ICC/IF, FC, IP Human

Related Diseases

Diseases Alias
Vaccinia
Variola Major

  • Smallpox
Myoclonic Epilepsy Of Lafora

  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Progressive Myoclonus Epilepsy

  • Pme

  • Progressive Myoclonic Epilepsy

  • Myoclonic Epilepsies, Progressive

  • Unverricht-Lundborg Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-123846 MLS-0437605 Inhibitor 99.27% Unkown
HY-RS04064 DUSP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17699 Dusp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24161 Dusp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DUSP3 VGNC VGNC:72012
Canis familiaris DUSP3 VGNC VGNC:53236
Felis catus DUSP3 VGNC VGNC:98903
Bos taurus DUSP3 VGNC VGNC:28259
Rattus norvegicus DUSP3 RGD RGD:1560049
Mus musculus DUSP3 MGD MGI:1919599
Others DUSP3 NCBI