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Cat. No.: HY-N19111

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TPI-2

TPI-2 is a metabolite found in the fungus Exophiala sp. TPI-2 induces increased glucose uptake in insulin-sensitive differentiated skeletal muscle cells, with dose-dependent activity. TPI-2 can be used in diabetes-related research.

For research use only. We do not sell to patients.

CAS No.: 110675-11-1
Formula: C₃₄H₄₈O₁₂
Molecular Weight:648.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TPI-2 Chemical Structure

CAS No.: 110675-11-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Fungal Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

TPI-2 (3-100 μM; 24 h) induces a dose-dependent increase in glucose uptake in differentiated L6 rat skeletal muscle myotubes, with activity equivalent to the standard Rosiglitazone (HY-17386)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:

L6 myotubes
Concentration:

3, 10, 30, 100 μM
Incubation Time:

24 h
Result:

Increased glucose uptake in insulin-sensitized differentiated L6 myotubes in a dose-dependent manner.
Exhibited bioactivity comparable to Rosiglitazone (HY-17386).

Chemical Information

CAS No. 110675-11-1
Molecular Weight 648.75
Formula C₃₄H₄₈O₁₂
SMILES

C(OC1=CC(CCCCCCC)=C(C(O)=O)C(O)=C1)(=O)C2=C(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2CCCCCCC
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Exophiala sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gohil AR et al. Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity. Nat Prod Res. 2021 May;35(10):1573-1581. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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TPI-2

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TPI-2 Related Classifications

HY-N19111 Related Classifications