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Cat. No.: HY-160654

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IRAK4 modulator-1

Name: IRAK4 modulator-1
Brand: MedChemExpress
SKU: HY-160654
Price: 65.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Customer Review

Based on 1 Customer Validation

IRAK4 modulator-1 (example 161) is a modulator of IRAK4 with IC₅₀=4.647 μM. IRAK4 modulator-1 can be used to study IRAK-mediated disorders.

For research use only. We do not sell to patients.

Purity : 99.11%
CAS No.: 1356014-97-5
Formula: C₁₉H₁₃ClN₄O₂
Molecular Weight:364.79

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

IRAK4 modulator-1 Chemical Structure

CAS No.: 1356014-97-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IRAK4 modulator-1 (example 161) is a modulator of IRAK4 with IC₅₀=4.647 μM. IRAK4 modulator-1 can be used to study IRAK-mediated disorders^[1].

IC₅₀ & Target

IRAK4

4.647 μM (IC₅₀, ^[1])

All IRAK Isoforms :

Chemical Information

CAS No. 1356014-97-5
Appearance Solid
Molecular Weight 364.79
Formula C₁₉H₁₃ClN₄O₂
Color White to off-white
SMILES

O=C(C1=C2N=CC=CN2N=C1)NC3=CC(Cl)=CC=C3OC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pyrazolo[1,5-a]pyrimidine and thieno[3,2-b]pyrimidine derivatives as IRAK4 modulators and their preparation. World Intellectual Property Organization, et al. World Intellectual Property Organization, WO2012007375 A1. 2012-01-19.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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