Isonixin  (Synonyms: Isonixine; Nixyn)

Isonixin (Isonixine) is a non-steroidal compound. Isonixin can be used for the research of pain and inflammation^[1][2][3][4].

Isonixine potentiates hexobarbital sleep time, reduces motor activity, antagonizes cardiazol-induced convulsions, causes hyperthermia, and inhibits tremorine-induced trembling in mice^[1].
Isonixine (p.o.) showes a 3.15 h half-life of absorption and rapidly absorbs in a gastro-intestinal tract^[2].
Isonixine (i.v., intragastrically and intraduodenally) mainly excrets via urine, and isonixine can be eliminated by urine within 50 hours^[3].
Isonixine (2000 mg/kg; p.o. once daily for 6 months) presents some mild toxic effects and induces no gastrointestinal lesion in male rabbits and rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

242.27

C₁₄H₁₄N₂O₂

57021-61-1

O=C(C1=CC=CNC1=O)NC2=C(C=CC=C2C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mitjavila MT, Martorell M. Algunos efectos de la isonixina sobre el sistema nervioso central [Various effects of isonixine on the central nervous system]. Arch Farmacol Toxicol. 1979 Dec;5(3):183-4.  [Content Brief]

  [2]. Carrera G, et al. Studies of absorption, distribution and excretion of 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine). Arzneimittelforschung. 1979;29(9):1401-4.  [Content Brief]

  [3]. Carrera G, et al. Etude pharmacocinétique de l'isonixine [Pharmacokinetic study of isonixine]. Arch Farmacol Toxicol. 1978 Apr;4(1):111-2.  [Content Brief]

  [4]. Mitjavila MT, et al. Toxicological investigations of isonixine. Arzneimittelforschung. 1977 Jul;27(7):1460-4.  [Content Brief]