Isotope-Labeled Nucleic Acids

(RS)-S-Adenosyl-L-methionine-d₃ (S-methyl-d₃) Tri(p-toluenesulfonate) Salt is the deuterium labeled (RS)-S-Adenosyl-L-methionine Tri(p-toluenesulfonate) Salt.

Uridine 5'-triphosphate (ammonium salt)-¹⁵N₂ is the ¹⁵N labeled Uridine 5'-triphosphate ammonium salt.

Guanosine 5'-triphosphate, ammonium salt-¹⁵N₅ is the ¹⁵N labeled Guanosine 5'-triphosphate, ammonium salt.

Cytidine 5'-triphosphate (ammonium salt)-d₂ is the deuterium labeled Cytidine 5'-triphosphate ammonium salt.

Uridine 5'-triphosphate (ammonium salt)-d₈ is the deuterium labeled Uridine 5'-triphosphate ammonium salt.

Guanosine 5'-triphosphate (GTP), ammonium salt-d₂₇ is the deuterium labeled Guanosine 5'-triphosphate (GTP), ammonium salt.

Cytidine 5'-Triphosphate (ammonium salt)-d₈ is the deuterium labeled Cytidine 5'-Triphosphate ammonium salt.

Adenosine 5'-Triphosphaye (ATP)-dd₁₆ , ammonium salt-dd₁₂ (1:4) is the deuterium labeled Adenosine 5'-Triphosphaye (ATP), ammonium salt (1:4).

Cytidine 5'-triphosphate-¹³C₉,¹⁵N₃ (ammonium) is the ¹³C and ¹⁵N labeled Cytidine 5'-triphosphate ammonium.

7-Methylguanine-d₃ is the deuterium labeled 7-Methylguanine. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.

Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication.

Propylthiouracil-d₅ (sodium) is the deuterium labeled Propylthiouracil sodium.

Thymine-d₄ is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.

6-Methylthioguanine-¹³C,d₃ is the ¹³C labeled 6-Methylthioguanine.

Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC₅₀ of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.

Cytosine-¹³C₂,¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.

Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

DMT-dT Phosphoramidite-¹³C is ¹³C-labeled DMT-dT Phosphoramidite (HY-W013068). DMT-dT Phosphoramidite is typically used in the synthesis of DNA.

DMT-dT Phosphoramidite-¹³C₁₀,¹⁵N₂ is the ¹³C and ¹⁵N labeled DMT-dT Phosphoramidite. DMT-dT Phosphoramidite is typically used in the synthesis of DNA.

DMT-dA(bz) Phosphoramidite-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled DMT-dA(bz) Phosphoramidite. DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA.