E2F5 - E2F transcription factor 5 Gene

Also Known as E2F-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1875

About E2F5

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,177,154-85,214,518 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 7 paralogues. Broad expression in lymph node (RPKM 12.6), thyroid (RPKM 6.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to Other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

E2F5 Products (3)

mRNA Protein Name
NM_001083588.2 NP_001077057.1 transcription factor E2F5 isoform 2
NM_001083589.2 NP_001077058.1 transcription factor E2F5 isoform 3
NM_001951.4 NP_001942.2 transcription factor E2F5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
17062573 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12502741 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F5 Protein Structure

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (50 - 116)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

transcription factor E2F5

  • E2F transcription factor 5, p130-binding

Related Diseases

Diseases Alias
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Retinal Cancer

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms

  • Malignant Retinal Neoplasm

  • Malignant Tumor Of Retina

  • Neoplasm Of Retina

  • Retinal Tumor

  • Retinal Neoplasm

  • Cancer Of The Retina

  • Malignant Retinal Tumour

  • Malignant Tumour Of Retina

  • Primary Malignant Neoplasm Of Retina
Familial Retinoblastoma

  • Hereditary Retinoblastoma

  • Retinoblastoma
Ocular Cancer

  • Eye Neoplasm

  • Eye Carcinoma

  • Eye Cancer

  • Eye Neoplasms

  • Malignant Eye Neoplasm

  • Neoplasm Of Eye

  • Neoplasm Of Eye Proper

  • Ocular Tumor

  • Carcinoma Of Eye

  • Ocular Carcinoma

  • Malignant Tumor Of Eye
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Soft Palate Cancer

  • Malignant Tumor Of Soft Palate

  • Malignant Tumor Of The Soft Palate

  • Palate Cancer Soft Palate
Retinal Disease

  • Retinal Diseases

  • Retinal Disorder

  • Retinal Disorders
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04114 E2F5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20723 E2f5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27235 E2f5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus E2F5 MGD MGI:105091
Macaca mulatta E2F5 VGNC VGNC:72026
Canis familiaris E2F5 VGNC VGNC:40167
Felis catus E2F5 VGNC VGNC:81648
Bos taurus E2F5 VGNC VGNC:28289
Rattus norvegicus E2F5 RGD RGD:621357
Others E2F5 NCBI