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Pou3f2 - POU domain, class 3, transcription factor 2 Gene

Also Known as Brn2; Otf7; Brn-2; OTF-7; oct-7; 9430075J19Rik; A230098E07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18992

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of gene expression. Acts upstream of or within several processes, including epidermis development; nervous system development; and regulation of axonogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; eye; future brain; genitourinary system; and thymus. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Pou3f2 Products (1)

mRNA	Protein	Name
NM_008899.2	NP_032925.1	POU domain, class 3, transcription factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12782656	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15465489	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	24243019	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15465489	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24643061	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17141158	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Schwann cell development	IGI IGI: Inferred from genetic interaction	12782656	MGI
acts upstream of or within cerebral cortex radially oriented cell migration	IGI IGI: Inferred from genetic interaction	12130536	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	8543156	MGI
acts upstream of or within forebrain astrocyte development	IMP IMP: Inferred from mutant phenotype	8543156	MGI
acts upstream of or within forebrain ventricular zone progenitor cell division	IGI IGI: Inferred from genetic interaction	12130536	MGI
acts upstream of or within hypothalamus cell differentiation	IMP IMP: Inferred from mutant phenotype	8543156	MGI
acts upstream of or within myelination in peripheral nervous system	IGI IGI: Inferred from genetic interaction	12782656	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23069940	MGI
involved in nervous system development	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	8543156	MGI
acts upstream of or within neurohypophysis development	IMP IMP: Inferred from mutant phenotype	8543156	MGI
involved in neuron development	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	17141158	MGI
involved in neuron differentiation	IDA IDA: Inferred from direct assay	24243019	MGI
involved in neuron fate commitment	IDA IDA: Inferred from direct assay	24243019	MGI
involved in neuron fate specification	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	8543156	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15465489	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17141158	MGI
acts upstream of or within regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	8543156	MGI
acts upstream of or within regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	8593698	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15465489	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24243019	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12782656	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12782656	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
POU domain, class 3, transcription factor 2	brain-2 class III POU-domain protein brain-specific homeobox/POU domain protein 2 nervous system-specific octamer-binding transcription factor N-Oct-3 octamer-binding protein 7 octamer-binding transcription factor 7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10901	POU3F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174478	Mouse Pou3f2 mRNA		/	Unkown
HY-174545	Human POU3F2 mRNA		/	Unkown
HY-RS21172	Pou3f2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27689	Pou3f2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou3f2	NCBI	NCBI:5454