NDUFA7 - NADH:ubiquinone oxidoreductase subunit A7 Gene

Also Known as B14.5a; CI-B14.5a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4701

About NDUFA7

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,308,595-8,321,375 (from NCBI)

This gene has 6 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in heart (RPKM 24.4), kidney (RPKM 16.8) and 25 other tissues.

Summary

This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

NDUFA7 Products (1)

mRNA Protein Name
NM_005001.5 NP_004992.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFA7 Protein Structure

CI-B14_5a

CI-B14_5a: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) (5 - 105)

  • 0
  • 100
  • 113 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa

NDUFA7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDUFA7 O95182 TTPA Homo sapiens P49638
Validated Y2H
32296183
Intra
NDUFA7 O95182 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra
NDUFA7 O95182 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09133 NDUFA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NDUFA7 MGD MGI:1913666
Rattus norvegicus NDUFA7 RGD RGD:1304597