NFKBIL1 - NFKB inhibitor like 1 Gene

Also Known as IKBL; NFKBIL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4795

About NFKBIL1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,546,851-31,558,829 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 181 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 7.9), fat (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

NFKBIL1 Products (4)

mRNA Protein Name
NM_001144961.2 NP_001138433.1 NF-kappa-B inhibitor-like protein 1 isoform 2
NM_001144962.2 NP_001138434.1 NF-kappa-B inhibitor-like protein 1 isoform 3
NM_001144963.2 NP_001138435.1 NF-kappa-B inhibitor-like protein 1 isoform 4
NM_005007.4 NP_004998.3 NF-kappa-B inhibitor-like protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20829348 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
20829348 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
20829348 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
20829348 GOA
involved in negative regulation of toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
20829348 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
20829348 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
20829348 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIL1 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (49 - 110)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

NF-kappa-B inhibitor-like protein 1

  • I-kappa-B-like protein

NFKBIL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NFKBIL1 Q9UBC1 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NFKBIL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89790 NFKBIL1 Antibody (YA9134) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09264 NFKBIL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NFKBIL1 VGNC VGNC:68487
Canis familiaris NFKBIL1 VGNC VGNC:43784
Bos taurus NFKBIL1 VGNC VGNC:32049
Mus musculus NFKBIL1 MGD MGI:1340031
Rattus norvegicus NFKBIL1 RGD RGD:1303310
Macaca mulatta NFKBIL1 VGNC VGNC:104414
Others NFKBIL1 NCBI