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NEUROD4 - neuronal differentiation 4 Gene

Also Known as ATH3; ATH-3; Atoh3; MATH3; MATH-3; bHLHa4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58158

About NEUROD4

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,019,974-55,030,017 (from NCBI)

This gene has 1 transcript (splice variant), 253 orthologues and 15 paralogues. Biased expression in adrenal (RPKM 1.3), brain (RPKM 0.2) and 1 other tissue.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in amacrine cell differentiation; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including Notch signaling pathway; camera-type eye development; and neurogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NEUROD4 Products (1)

mRNA	Protein	Name
NM_021191.3	NP_067014.2	neurogenic differentiation factor 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEUROD4 Protein Structure

HLH

Neuro_bHLH

0
100
200
300
331 a.a.

Protein Preferred Names	Protein Names
neurogenic differentiation factor 4	class A basic helix-loop-helix protein 4

NEUROD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NEUROD4	Q9HD90	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	NEUROD4	Q9HD90	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cardiac Valvular Dysplasia, X-Linked	Xmvd X-Linked Cardiac Valvular Dysplasia CVD1 Filamin A-Related X-Linked Myxomatous Valvular Dysplasia Flna-Related Valvular Dystrophy Flna-Related X-Linked Myxomatous Valvular Dysplasia Valvular Heart Disease, Congenital Myxomatous Valvular Dystrophy, X-Linked Congenital Valvular Heart Disease X-Linked Myxomatous Valvular Dystrophy CVDPX Ehlers-Danlos Syndrome, Type V, Formerly Eds5, Formerly Dystrophie Valvulaire Associee A Flna Eds 5 Ehlers-Danlos Syndrome, Type 5 Dystrophie Valvulaire Associée À Flna Filamin-A-Associated Myxomatous Mitral Valve Disease Filamin-A-Related Myxomatous Mitral Valve Dystrophy Congenital Valvular Dysplasia Cvdx Ehlers-Danlos Syndrome Type 5
Panhypopituitarism, X-Linked	PHPX X-Linked Panhypopituitarism Pituitary Dwarfism Iv Panhypopituitarism X-Linked Pituitary Dwarfism Iv, Formerly Panhypopituitarism - X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03949	DPF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09226	NEUROD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NEUROD4	VGNC	VGNC:43754
Rattus norvegicus	NEUROD4	RGD	RGD:1310434
Felis catus	NEUROD4	VGNC	VGNC:63784
Mus musculus	NEUROD4	MGD	MGI:108055
Bos taurus	NEUROD4	VGNC	VGNC:32019
Others	NEUROD4	NCBI