SOAT1 - sterol O-acyltransferase 1 Gene

Also Known as ACAT; SOAT; STAT; ACACT; ACAT1; ACAT-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6646

About SOAT1

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:179,293,797-179,358,680 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 2 paralogues. Broad expression in adrenal (RPKM 68.9), prostate (RPKM 11.4) and 17 other tissues.

Summary

The protein encoded by this gene belongs to the Acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free Cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

SOAT1 Products (3)

mRNA	Protein	Name
NM_001252511.2	NP_001239440.1	sterol O-acyltransferase 1 isoform 2
NM_001252512.2	NP_001239441.1	sterol O-acyltransferase 1 isoform 3
NM_003101.6	NP_003092.4	sterol O-acyltransferase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cholesterol O-acyltransferase activity	IDA IDA: Inferred from direct assay	16647063	GOA
enables cholesterol O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	8407899	GOA
enables cholesterol binding	IDA IDA: Inferred from direct assay	16647063	GOA
enables fatty-acyl-CoA binding	IDA IDA: Inferred from direct assay	16647063	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32433613	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables sterol O-acyltransferase activity	IDA IDA: Inferred from direct assay	9756919	GOA
enables sterol O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	8407899	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	15308631	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	32433614	GOA
acts upstream of or within cholesterol metabolic process	IDA IDA: Inferred from direct assay	9756919	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	16647063	GOA
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	8407899	GOA
involved in cholesterol storage	IMP IMP: Inferred from mutant phenotype	8407899	GOA
involved in macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	8407899	GOA
involved in positive regulation of amyloid precursor protein biosynthetic process	IMP IMP: Inferred from mutant phenotype	17412327	GOA
involved in very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	15308631	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10623671	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17412327	GOA
located in membrane	IDA IDA: Inferred from direct assay	9756919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOAT1 Protein Structure

MBOAT

0
100
200
300
400
500
550 a.a.

Protein Preferred Names	Protein Names
sterol O-acyltransferase 1	acyl-coenzyme A:cholesterol acyltransferase 1

SOAT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SOAT1	P35610	CARNMT1	Homo sapiens	Q8N4J0	Anti Tag CoIP	28514442
Intra	SOAT1	P35610	CARNMT1	Homo sapiens	Q8N4J0	Anti Tag CoIP	33961781
Intra	SOAT1	P35610	UBIAD1	Homo sapiens	Q9Y5Z9	Anti Tag CoIP	23169578
Intra	SOAT1	P35610	TERF1	Homo sapiens	P54274	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Adrenal Carcinoma	Adrenal Cancer Adrenal Gland Cancer Malignant Neoplasm Of Adrenal Gland Adrenal Gland Neoplasms Carcinoma Of The Adrenal Gland Adrenal Neoplasm Malignant Adrenal Tumor Neoplasm Of Adrenal Gland Tumor Of The Adrenal Gland Adrenal Gland Neoplasm Adrenocortical Carcinoma Adrenal Gland Malignancy Suprarenal Cancer Malignant Neoplasm Of Suprarenal Gland Malignant Neoplasm Of Adrenal Gland, Unspecified Malignant Tumour Of Adrenal Gland Suprarenal Gland Cancer Primary Malignant Neoplasm Of Adrenal Gland
Schnyder Corneal Dystrophy	Schnyder Crystalline Corneal Dystrophy SCCD Corneal Dystrophy, Crystalline, Of Schnyder Corneal Dystrophy, Schnyder Type Corneal Dystrophy Crystalline Of Schnyder Crystalline Stromal Dystrophy Hereditary Crystalline Stromal Dystrophy Of Schnyder Scd Corneal Dystrophy, Schnyder Schnyder Crystalline Dystrophy Sine Crystals Dystrophy, Corneal, Crystalline, Schnyder
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Adrenal Cortex Disease	Adrenal Cortex Diseases
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160804	Desmethyl nevanimibe		98.40%	Unkown
HY-RS13549	SOAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-135727	PF-6422899	Inhibitor	/	Unkown
HY-RS18683	Soat1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25169	Soat1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SOAT1	VGNC	VGNC:35116
Mus musculus	SOAT1	MGD	MGI:104665
Macaca mulatta	SOAT1	VGNC	VGNC:77685
Canis familiaris	SOAT1	VGNC	VGNC:46646
Felis catus	SOAT1	VGNC	VGNC:65561
Rattus norvegicus	SOAT1	RGD	RGD:621641
Others	SOAT1	NCBI