ZYG11B - zyg-11 family member B, cell cycle regulator Gene

Also Known as ZYG11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79699

About ZYG11B

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,726,453-52,827,336 (from NCBI)

This gene has 2 transcripts (splice variants), 271 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.7) and 25 other tissues.

Summary

Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZYG11B Products (1)

mRNA Protein Name
NM_024646.3 NP_078922.1 protein zyg-11 homolog B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17304241 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
31273098 GOA
involved in protein quality control for misfolded or incompletely synthesized proteins IMP
IMP: Inferred from mutant phenotype
31273098 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
31273098 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein zyg-11 homolog B

  • zyg-11 homolog B

ZYG11B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZYG11B Q9C0D3 CUL2 Homo sapiens Q13617
Anti Tag CoIP
17304241
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Craniofacial Microsomia

  • Goldenhar Syndrome

  • Hemifacial Microsomia

  • Oculoauriculovertebral Spectrum

  • Oavs

  • Oculo-Auriculo-Vertebral Spectrum

  • CFM

  • Oav Dysplasia

  • Facioauriculovertebral Sequence

  • Fav Sequence

  • First And Second Branchial Arch Syndrome

  • Otomandibular Dysostosis

  • Hfm

  • Oculoauriculovertebral Dysplasia

  • Facio-Auriculo-Vertebral Spectrum

  • Facioauriculovertebral Dysplasia

  • Oculo-Auriculo-Vertebral Dysplasia

  • First Arch Syndrome

  • Oav Dysplasia

  • Goldenhar Disease

  • Expanded Spectrum Hemifacial Microsomia

  • Expanded Spectrum Of Hemifacial Microsomia

  • Oculoauriculovertebral Syndrome

  • Oavd

  • Asymmetric Hypoplasia Of Facial Structures

  • Auriculobranchiogenic Dysplasia

  • Fav

  • First And Second Pharyngeal Arch Syndromes

  • Goldenhar-Gorlin Syndrome

  • Lateral Facial Dysplasia

  • Oav Complex

  • Oral-Mandibular-Auricular Syndrome

  • Unilateral Intrauterine Facial Necrosis

  • Unilateral Mandibulofacial Dysostosis

  • Oav Spectrum

  • Oculoauricular Vertebral Dysplasia

  • Microsomia, Hemifacial

  • Goldenhar Syndrome With Ipsilateral Radial Defect
Cardiomyopathy, Familial Hypertrophic, 26

  • Hypertrophic Cardiomyopathy 26

  • CMH26

  • Cardiomyopathy, Familial Restrictive 5

  • Cardiomyopathy, Familial Restrictive, 5

  • Cardiomyopathy Familial Hypertrophic 26

  • Cardiomyopathy, Familial Hypertrophic 26

  • RCM5
Noonan Syndrome 12

  • NS12
Branchiootic Syndrome

  • Bo Syndrome

  • Branchiootic Dysplasia

  • Bor

  • Bo Syndrome 1

  • Bos1

  • Branchiootic Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16214 ZYG11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZYG11B VGNC VGNC:100197
Felis catus ZYG11B VGNC VGNC:67393
Bos taurus ZYG11B VGNC VGNC:37394
Mus musculus ZYG11B MGD MGI:2685277
Canis familiaris ZYG11B VGNC VGNC:48869
Rattus norvegicus ZYG11B RGD RGD:1307814
Others ZYG11B NCBI