MAT2A-IN-13
MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors research.
For research use only. We do not sell to patients.
- CAS No.: 2851449-24-4
- Formula: C17H12F4N4O
- Molecular Weight:364.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.273 μM
Compound: 30
|
Antiproliferative activity against MTAP knockout human HCT-116 assessed as inhibition of cell proliferation incubated for 6 days by alamar blue reagent based analysis
Antiproliferative activity against MTAP knockout human HCT-116 assessed as inhibition of cell proliferation incubated for 6 days by alamar blue reagent based analysis
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[PMID: 38116423] |
Chemical Information
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CAS No. 2851449-24-4
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Molecular Weight 364.30
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Formula C17H12F4N4O
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SMILES
O=C1C(C2=CC=CN=C2F)=C(C=C(C(F)(F)F)C=C3)N3C(NC4CC4)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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