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STING-IN-2

11 Cited Publications
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Based on 11 publication(s) in Google Scholar

STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research.

For research use only. We do not sell to patients.

  • Purity: 99.39%
  • CAS No.: 346691-38-1
  • Formula: C15H16N2O4
  • Molecular Weight:288.30
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • STING-IN-2 Chemical Structure
    STING-IN-2 Chemical Structure
  • Experimental Validation Results for STING-IN-2
  • Experimental Validation Results for STING-IN-2
  • Experimental Validation Results for STING-IN-2
  • Experimental Validation Results for STING-IN-2
  • Experimental Validation Results for STING-IN-2
CAS No.: 346691-38-1
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  • STING-IN-2 Chemical Structure
    STING-IN-2 Chemical Structure
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    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17. [Abstract]

    Customer Validation
     STING-IN-2 (1 μM; 24 h) significantly reduced the level of p-TBK1 in Lv-shAtg7 chondrocytes, a key kinase responsible for STING1 signal transduction.

  • 1/16

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17. [Abstract]

    Customer Validation
     Quantification of mRNA levels of Col2a1 and acan in the Lv-shAtg7 chondrocytes treated with STING-IN-2 (1 μM; 24 h).

  • 1/16

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17. [Abstract]

    Customer Validation
     STING-IN-2 (1 μM; 24 h) partially abolished the increased phosphorylation levels of MAPK14 (p-MAPK14) and MAP2K3/MKK3 (p-MAP2K3, a MAPK kinase responsible for MAPK14 activation) in Lv-shAtg7 chondrocytes.

  • 1/16

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. [Abstract]

    Customer Validation
     STING-IN-2 (C-170) (4 mM; 2 h) largely abrogated the phosphorylation of PRPS1/2 T228 in the irradiated FHs 74 Int cells.

  • 1/16

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. [Abstract]

    Customer Validation
     STING-IN-2 (C-170) (4 mM; 2 h) abolished ionizing radiation-induced PRPS1/2 activity in FHs 74 Int cells.

  • STING-IN-2