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Cat. No.: HY-113917

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JNJ 40279486

JNJ 40279486 is a novel and highly selective histamine H₄ receptor antagonist with a K_i of 9 nM. JNJ 40279486 can be used in the research of immune-driven inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 1002351-34-9
Formula: C₁₄H₁₅ClN₆O
Molecular Weight:318.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

JNJ 40279486 Chemical Structure

CAS No.: 1002351-34-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JNJ 40279486 is a novel and highly selective histamine H₄ receptor antagonist with a K_i of 9 nM. JNJ 40279486 can be used in the research of immune-driven inflammatory diseases^[1].

IC₅₀ & Target^[1]

H₄ receptor

9 nM (Ki)

All Histamine Receptor Isoforms :

Chemical Information

CAS No. 1002351-34-9
Molecular Weight 318.77
Formula C₁₄H₁₅ClN₆O
SMILES

NC=1N=C2C(=C(N1)N3C[C@H](NC)CC3)OC=4C2=CC(Cl)=CN4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Savall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists. J Med Chem. 2014 Mar 27;57(6):2429-39. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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JNJ 40279486

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNJ 40279486 Related Classifications

HY-113917 Related Classifications