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Cat. No.: HY-122874

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DI-404

DI-404 is a potent inhibitor of DCN1 with a KK_d value of 6.7 nM. DI-404 selectively inhibits neddylation of cullin 3 in a dose-dependent manner.

For research use only. We do not sell to patients.

CAS No.: 2187412-79-7
Formula: C₃₅H₄₅ClN₆O₆S
Molecular Weight:713.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DI-404 Chemical Structure

CAS No.: 2187412-79-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DI-404 is a potent inhibitor of DCN1 with a KK_d value of 6.7 nM. DI-404 selectively inhibits neddylation of cullin 3 in a dose-dependent manner^[1].

Chemical Information

CAS No. 2187412-79-7
Molecular Weight 713.29
Formula C₃₅H₄₅ClN₆O₆S
SMILES

O=C(N[C@@H]1CCOC2=C1C=CC=C2)[C@@H](NC([C@@H](NC([C@@H](NC(CC)=O)CC3=NC4=CC=C(Cl)C=C4S3)=O)C5CCOCC5)=O)CCCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou H, et al. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Mar 8;61(5):1934-1950. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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