SF3A1 - splicing factor 3a subunit 1 Gene

Also Known as PRP21; PRPF21; SAP114; SF3A120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10291

About SF3A1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,331,988-30,356,894 (from NCBI)

This gene has 10 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 34.4), ovary (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]

SF3A1 Products (1)

mRNA Protein Name
NM_005877.6 NP_005868.1 splicing factor 3A subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
10882114 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10976766 GOA
Biological Process GO Annotation Evidence References Source
involved in U2-type prespliceosome assembly IDA
IDA: Inferred from direct assay
10882114 GOA
involved in mRNA processing IMP
IMP: Inferred from mutant phenotype
15647371 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
10882114 GOA
Cellular Component GO Annotation Evidence References Source
part of U2 snRNP IDA
IDA: Inferred from direct assay
10882114 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
10882114 GOA
part of U2-type prespliceosome IDA
IDA: Inferred from direct assay
10882114 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
10882114 GOA
part of U2-type spliceosomal complex IPI
IPI: Inferred from physical interaction
10882114 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
21349847 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10882114 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
9731529 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3A1 Protein Structure

Surp

Surp: Surp module (50 - 102)

Surp

Surp: Surp module (163 - 215)

PRP21_like_P

PRP21_like_P: Pre-mRNA splicing factor PRP21 like protein (226 - 472)

ubiquitin

ubiquitin: Ubiquitin family (722 - 788)

  • 0
  • 200
  • 400
  • 600
  • 793 a.a.
Protein Preferred Names Protein Names

splicing factor 3A subunit 1

  • SAP 114

SF3A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SF3A1 Q15459 SF3A3 Homo sapiens Q12874
Anti Tag CoIP
33961781
Intra
SF3A1 Q15459 SF3A3 Homo sapiens Q12874
Anti Tag CoIP
28514442
Intra
SF3A1 Q15459 SF3A3 Homo sapiens Q12874
Anti Tag CoIP
22365833
Intra
SF3A1 Q15459 SF3A3 Homo sapiens Q12874
Y2H
22365833
Intra
SF3A1 Q15459 SF3A3 Homo sapiens Q12874
Anti Tag CoIP
35271311
Intra
SF3A1 Q15459 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
22365833
Intra
SF3A1 Q15459 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
35271311
Intra
SF3A1 Q15459 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
20562859
Intra
SF3A1 Q15459 SP1 Homo sapiens P08047
Y2H
10976766
Intra
SF3A1 Q15459 PRPF40A Homo sapiens O75400
Anti Tag CoIP
35271311
Intra
SF3A1 Q15459 RBM10 Homo sapiens P98175
Y2H
22365833
Intra
SF3A1 Q15459 SF1 Homo sapiens Q15637
Pull Down
26420826
Intra
SF3A1 Q15459 SF1 Homo sapiens Q15637
Y2H
22365833
Intra
SF3A1 Q15459 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 61

  • RP61

  • Retinitis Pigmentosa, Type 61
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-111517 H3B-8800 98.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16399 Pladienolide B 99.20% Unkown
HY-16466 Spliceostatin A 96.64% Unkown
HY-141881 PROTAC-O4I2 99.56% Unkown
HY-168534 WX-02-23 99.88% Unkown
HY-162386 UM4118 99.95% Unkown
HY-181421 WX-02-43 Ligand 99.49% Unkown
HY-158783 SACLAC 99.70% Unkown
HY-114461B (3S,17S)-FD-895 / Unkown
HY-120907 Sudemycin E Ligand / Unkown
HY-122637 Sudemycin K Inhibitor / Unkown
HY-15867 Meayamycin B / Unkown
HY-RS12757 SF3A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12760 SF3B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17082 Sf3b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23526 Sf3b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SF3A1 VGNC VGNC:65052
Bos taurus SF3A1 VGNC VGNC:34506
Rattus norvegicus SF3A1 RGD RGD:1311477
Mus musculus SF3A1 MGD MGI:1914715
Canis familiaris SF3A1 VGNC VGNC:46067
Macaca mulatta SF3A1 VGNC VGNC:77177
Others SF3A1 NCBI