TRIM25 - tripartite motif containing 25 Gene

Also Known as EFP; Z147; RNF147; ZNF147

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7706

About TRIM25

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,887,909-56,914,049 (from NCBI)

This gene has 12 transcripts (splice variants), 125 orthologues and 80 paralogues. Ubiquitous expression in bone marrow (RPKM 21.8), skin (RPKM 15.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 Ligase and is involved in multiple cellular processes, including regulation of Antiviral innate immunity. [provided by RefSeq, Sep 2021]

TRIM25 Products (1)

mRNA	Protein	Name
NM_005082.5	NP_005073.2	E3 ubiquitin/ISG15 ligase TRIM25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RIG-I binding	IPI IPI: Inferred from physical interaction	23950712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19454348	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16352599	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	24810856	GOA
enables ubiquitin-protein transferase activity	EXP EXP: Inferred from Experiment	17392790	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	24810856	GOA
NOT involved in RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	31006531	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	17392790	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	17392790	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	36075446	GOA
involved in protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	24810856	GOA
involved in regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in response to estrogen	IDA IDA: Inferred from direct assay	22452784	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	36075446	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22452784	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	23950712	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	23950712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM25 Protein Structure

zf-C3HC4_4

PRY

SPRY

0
100
200
300
400
500
600
630 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin/ISG15 ligase TRIM25	RING finger protein 147

TRIM25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	TRIM25	Q14258	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34452305
Cross	TRIM25	Q14258	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34471099
Cross	TRIM25	Q14258	NSS	sfts virus hb29	A0A0B5AC19	Confocal	24478431
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	BiFC	24478431
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Anti Tag CoIP	34452305
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Anti Tag CoIP	34471099
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Confocal	34471099
Cross	TRIM25	Q14258	NS	Influenza A virus	P03496	Anti Bait CoIP	19454348
Cross	TRIM25	Q14258	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	Anti Tag CoIP	32295922

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIM25 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82533	TRIM25 Antibody (YA2278)	WB, ICC/IF, IP	Human, Rat
HY-P82533A	TRIM25 Antibody (YA2278)(PBS only)	WB, ICC/IF, IP	Human, Rat
HY-P84567	TRIM25 Antibody (YA4264)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84567A	TRIM25 Antibody (YA4264)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Gingival Recession	Localized Gingival Recession Gingival Recession, Localized Minimal Gingival Recession Moderate Gingival Recession Severe Gingival Recession Gingival Recession, Minimal Gingival Recession, Severe Atrophy Of Gums Gum Atrophy Gingival Atrophy
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Gingival Disease	Gingival Diseases Gum Disease Gingival Disorder Gingivitis And Periodontal Diseases
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162065	N6F11	Inducer	98.11%	Unkown
HY-RS15030	TRIM25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174853	TRIM25 ligand-1	Ligand	/	Unkown
HY-177815	R-1 sodium	Inhibitor	/	Unkown
HY-177816	R-2 sodium	Inhibitor	/	Unkown
HY-183638	T7117	Inhibitor	/	Unkown
HY-RS18314	Trim25 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24792	Trim25 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM25	VGNC	VGNC:47810
Felis catus	TRIM25	VGNC	VGNC:66531
Macaca mulatta	TRIM25	VGNC	VGNC:78847
Rattus norvegicus	TRIM25	RGD	RGD:1594396
Mus musculus	TRIM25	MGD	MGI:102749
Bos taurus	TRIM25	VGNC	VGNC:36322
Others	TRIM25	NCBI