2-Quinoxalinecarboxylic acid
Based on 1 Customer Validation
2-Quinoxalinecarboxylic acid is an antibacterial agent targeting Mycobacterium tuberculosis (MIC: >128 µg/mL). 2-Quinoxalinecarboxylic acid is promising for research of tuberculosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.20%
- CAS 番号: 879-65-2
- 分子式: C9H6N2O2
- 分子量:174.16
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-W017534
Brimonidine impurity 7Drug Impurity -
HY-W041703
6-Amino-5-bromoquinoxaline -
HY-W017519
2-QuinoxalinolQuinoline Derivative -
HY-W015672
2-MethylquinoxalineDetection Marker -
HY-W017534R
Quinoxalin-6-amine (Standard) -
HY-W017519R
2-Quinoxalinol (Standard)Quinoline Derivative -
HY-W041533
5,6,7,8-TetrahydroquinoxalineFlavor Enhancer -
HY-20803
2,3-DihydroxyquinoxalineFluorescent Reagent -
HY-69094
6-BromoquinoxalineBiochemical Reagent -
HY-W016099
3-Methyl-2-quinoxalinecarboxylic acid -
HY-W016099S
3-Methyl-2-quinoxalinecarboxylic acid-d4Stable Isotope -
HY-W002071S
2-Quinoxalinecarboxylic acid-d4Stable Isotope
生物活性
製品説明
化学情報
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CAS 番号 879-65-2
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性状 Solid
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分子量 174.16
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分子式 C9H6N2O2
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Color Off-white to light brown
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SMILES
O=C(C1=NC2=CC=CC=C2N=C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (574.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7418 mL | 28.7092 mL | 57.4185 mL | 143.5462 mL |
| 5 mM | 1.1484 mL | 5.7418 mL | 11.4837 mL | 28.7092 mL | |
| 10 mM | 0.5742 mL | 2.8709 mL | 5.7418 mL | 14.3546 mL | |
| 15 mM | 0.3828 mL | 1.9139 mL | 3.8279 mL | 9.5697 mL | |
| 20 mM | 0.2871 mL | 1.4355 mL | 2.8709 mL | 7.1773 mL | |
| 25 mM | 0.2297 mL | 1.1484 mL | 2.2967 mL | 5.7418 mL | |
| 30 mM | 0.1914 mL | 0.9570 mL | 1.9139 mL | 4.7849 mL | |
| 40 mM | 0.1435 mL | 0.7177 mL | 1.4355 mL | 3.5887 mL | |
| 50 mM | 0.1148 mL | 0.5742 mL | 1.1484 mL | 2.8709 mL | |
| 60 mM | 0.0957 mL | 0.4785 mL | 0.9570 mL | 2.3924 mL | |
| 80 mM | 0.0718 mL | 0.3589 mL | 0.7177 mL | 1.7943 mL | |
| 100 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4355 mL |
2-Quinoxalinecarboxylic acid 関連分類
HY-W002071 関連分類
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