製品番号: HY-N0664

アウクビン

(別名: Aucubin)

10 Cited Publications

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.98%
CAS 番号: 479-98-1
分子式: C₁₅H₂₂O₉
分子量:346.33

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Aucubin 構造式

CAS 番号: 479-98-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (10)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>10 μM Compound: 24	Cytotoxicity against human A2780 cells by MTT assay Cytotoxicity against human A2780 cells by MTT assay	[PMID: 26859776]
A549	IC₅₀	>10 μM Compound: 24	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 26859776]
Bel-7402	IC₅₀	>10 μM Compound: 24	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 26859776]
BGC-823	IC₅₀	>10 μM Compound: 24	Cytotoxicity against human BGC823 cells by MTT assay Cytotoxicity against human BGC823 cells by MTT assay	[PMID: 26859776]
HT-29	IC₅₀	>10 μM Compound: 24	Cytotoxicity against human HT-29 cells by MTT assay Cytotoxicity against human HT-29 cells by MTT assay	[PMID: 26859776]

体外実験

Aucubin (0.001-1 μg/mL; pretreated for 30 min) dose-dependently inhibits IgE-induced TNF-α and IL-6 production and expression in RBL-2H3 cells, with IC₅₀s of 0.101 and 0.19 μg/mL, respectively^[2].
Aucubin (0.01 μg/mL; pretreated for 30 min) inhibits IgE-induced nuclear translocation of p65 subunit of NF-κB and degradation of IκBα in RBL-2H3 cells^[2].
Aucubin (0.001-1 mM; 12 h) increases PC12 cellular viability and markedly inhbits H₂O₂-induced apoptotic cell death^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Aucubin (5 mg/kg; i.p. for 15 d) has antioxidant and pancreas-protective effects on rats with streptozotocin-induced diabetes^[1].
Aucubin (40-200 mg/kg; a single i.p.) exhibits significant protective activity against α-amanitin intoxication in mice^[5].
Aucubin (5 mg/kg/day; i.p. for 21 d) decreases the breathing frequency, increases the lung dynamic compliance, alleviates lung parenchymal fibrotic changes, and reduces the intrapulmonary collagen disposition and inflammatory injury of BLM-stimulated mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (200-230 g) induced diabetes by a injection of streptozotocin^[1]
Dosage:

5 mg/kg
Administration:

I.p. twice daily for the first 5 days, followed by single injections daily for the last 10 days
Result:

Increased the body weight of streptozotocin-diabetic rats.
Lowered the blood glucose level.
Decreased the level of lipid peroxidation and increased the activities of antioxidant enzymes.
Increased in insulin immunoreactivity and the number of immunoreactive β cells compared with untreated diabetic rats.

化学情報

CAS 番号 479-98-1
性状 Solid
分子量 346.33
分子式 C₁₅H₂₂O₉
Color White to light yellow
SMILES

O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H](OC=C2)[C@@]3([H])[C@]2([H])[C@H](O)C=C3CO
別名

Aucubin
Structure Classification
- Terpenoids
- Iridoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (10)

All Cell Imaging/StainingRT-PCRIn Vivo Efficacy StudyCell Proliferation/Viability AssayWBBio/Physico-chemical Assay

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Journal Impact Factor

Stem Cell Res Ther

Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs. [Abstract]

2022 Aug 19;13(1):424. PMID: 35986345

Aucubin purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2022 Aug 19;13(1):424. [Abstract]

Aubucin (AU, 0.01-1 μmol/L). Immunofluorescence staining for COL1A1 and RUNX2 proteins after 3 days of osteogenesis. Scale bars, 50 μm. Western blotting analysis indicated that the protein expression of osteogenesis-related genes (COL1A1, RUNX2 and SP7) was significantly increased at concentrations of 0.1 μM and 1 μM on day 3 of osteogenesis compared to control group.

Aucubin purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2022 Aug 19;13(1):424. [Abstract]

Different concentrations of Aubucin (AU, 0–1 μM) promoted hBM-MSCs mineralization and ALP activity. ALP staining and activity was detected on day 3 of osteogenesis. ARS staining and quantitation was detected on day 14 of osteogenesis. Scale bars, 500 μm.
Biochem Pharmacol

Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway. [Abstract]

2023 Mar:209:115440. PMID: 36720354

Aucubin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2023 Mar:209:115440. [Abstract]

The cultured mice cochlear explants were divided into control (no treatment), cisplatin only (20 μM cisplatin for 24 h), Aucubin only (Au, 150 μM Aucubin for 24 h), and cisplatin plus Aucubin (150 μM Aucubin pre-treatment for 4 h, followed by combined cisplatin and Aucubin treatment for 24 h) groups. Representative images showing that the apical, middle, and basal turns of the cochlear explants treated with cisplatin plus Aucubin (Cis + Au) had significantly more HCs compared to the cisplatin group (Cis).

Aucubin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2023 Mar:209:115440. [Abstract]

6 mice were administered 20 μM cisplatin in the right ear and 20 μM cisplatin plus 150 μM Aucubin (Au,single dose) in the left ear, while another 6 mice were administered 150 μM Aucubin in the right ear and equivalent normal saline in the left ear. Transtympanic injection of Aucubin injection substantially alleviated the ABR threshold shift caused by cisplatin at 8, 16, and 22.6 kHz. n = 6.
Pharmaceuticals (Basel)

The Analgesia Effect of Aucubin on CFA-Induced Inflammatory Pain by Inhibiting Glial Cells Activation-Mediated Inflammatory Response via Activating Mitophagy. [Abstract]

2023 Nov 1;16(11):1545. PMID: 38004411

Aucubin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2023 Nov 1;16(11):1545. [Abstract]

Aucubin (10 mg/kg; i.p.; once daily for 3 days) attenuated CFA-induced mechanical allodynia and thermal hyperalgesia in mice.
Bioorg Chem

Aucubin attenuates neonatal hypoxic-ischemic brain injury by suppressing NLRP3 inflammasome-mediated microglial pyroptosis. [Abstract]

2026 Jan:168:109332. PMID: 41365065
Int Immunopharmacol

Neuroprotective effects of Aucubin against cerebral ischemia-reperfusion injury. [Abstract]

2024 Mar 10:129:111648. PMID: 38335656

Aucubin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111648. [Abstract]

Microglia was pretreated with various concentrations of AU (Aucubin; 50-100 μM) for 2 h followed by LPS treatment (100 ng/ml). The mRNA levels of TNF-α, IL‐1β, iNOS, and IL‐6 were measured using real‐time PCR after LPS treatment for 24 h with or without AU.

Aucubin purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111648. [Abstract]

Primary microglia were treated with/without AU (Aucubin) in a dose-dependent manner (0,1,10,100,500,1000 and 10000 μM) for 24 h, then CCK-8 assay was added to detect cell viability, respectively. n = 4 per group. AU at lower concentrations (0 to 500 μM) didn't affect the microglial viability, whereas higher concentrations (1000 to 10000 μM) of AU significantly decreased microglial viability.
Int Immunopharmacol

Attenuated memory impairment and neuroinflammation in Alzheimer's disease by aucubin via the inhibition of ERK-FOS axis. [Abstract]

2024 Jan 5:126:111312. PMID: 38043266
Viruses

Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo. [Abstract]

2025 Apr 27;17(5):628. PMID: 40431640
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Medicine (Baltimore)

Integrating network pharmacology, molecular docking, and experimental validation to reveal the mechanism of Radix Rehmanniae in psoriasis. [Abstract]

2024 Oct 25;103(43):e40211. PMID: 39470475
Research Square Preprint

2021 Feb.

溶剤 & 溶解度

体外:

H₂O : ≥ 100 mg/mL (288.74 mM)

DMSO : 100 mg/mL (288.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8874 mL

14.4371 mL

28.8742 mL

5 mM

0.5775 mL

2.8874 mL

5.7748 mL

10 mM

0.2887 mL

1.4437 mL

2.8874 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (7.22 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (284 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jin l, et, al. Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes. Eur J Pharmacol. 2008 Mar 17;582(1-3):162-7. [Content Brief]

[2]. Jeong HJ, et, al. Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells. Cytokine. 2002 Jun 7;18(5):252-9. [Content Brief]

[3]. Zeng X, et, al. A review of the pharmacology and toxicology of aucubin. Fitoterapia. 2020 Jan;140:104443. [Content Brief]

[4]. Xue HY, et, al. Protective effects of aucubin on H₂O₂-induced apoptosis in PC12 cells. Phytother Res. 2012 Mar;26(3):369-74. [Content Brief]

[5]. Chang LM, et, al. Aucubin: potential antidote for alpha-amanitin poisoning. J Toxicol Clin Toxicol. 1984 Jul;22(1):77-85. [Content Brief]

[6]. Zhou Y, et, al. Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model. Inflammation. 2017 Dec;40(6):2062-2073. [Content Brief]

[7]. Liu P, et al. Aucubin improves chronic unpredictable mild stress-induced depressive behavior in mice via the GR/NF-κB/NLRP3 axis. Int Immunopharmacol. 2023 Oct;123:110677. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.8874 mL	14.4371 mL	28.8742 mL	72.1855 mL
	5 mM	0.5775 mL	2.8874 mL	5.7748 mL	14.4371 mL
	10 mM	0.2887 mL	1.4437 mL	2.8874 mL	7.2185 mL
	15 mM	0.1925 mL	0.9625 mL	1.9249 mL	4.8124 mL
	20 mM	0.1444 mL	0.7219 mL	1.4437 mL	3.6093 mL
	25 mM	0.1155 mL	0.5775 mL	1.1550 mL	2.8874 mL
	30 mM	0.0962 mL	0.4812 mL	0.9625 mL	2.4062 mL
	40 mM	0.0722 mL	0.3609 mL	0.7219 mL	1.8046 mL
	50 mM	0.0577 mL	0.2887 mL	0.5775 mL	1.4437 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2031 mL
	80 mM	0.0361 mL	0.1805 mL	0.3609 mL	0.9023 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7219 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Aucubin

10 Cited Publications

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MedChemExpress（MCE）の使用を引用している文献 Aucubin

生物活性

化学情報

Publications (10)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Aucubin 関連分類

製品番号: HY-N0664