country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-100260

Copy Link Print Information

beta-L-D4A

(別名: 2'3'-didehydro-2'3'-dideoxyadenosine)

カスタマーレビュー

Based on 1 Customer Validation

beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.71%
CAS 番号: 7057-48-9
分子式: C₁₀H₁₁N₅O₂
分子量:233.23

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

beta-L-D4A 構造式

CAS 番号: 7057-48-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor.

IC₅₀ & Target^[1]

HIV-1

HIV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
ATH-8 cell line	ED₅₀	40 μM Compound: 2c	Protection of ATH8 cells against the cytopathic effect of HIV. Protection of ATH8 cells against the cytopathic effect of HIV.	[PMID: 3497272]
C3H	CC₅₀	>100 μM Compound: 2[d4A]	Compound was evaluated cytotoxicity against moloney sarcoma virus (MSV) infected C3H cell cultures. Compound was evaluated cytotoxicity against moloney sarcoma virus (MSV) infected C3H cell cultures.	10.1016/0960-894X(96)00433-7
C3H/3T3	EC₅₀	35 μM Compound: 3	Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts	[PMID: 10229629]
CCRF-CEM	CC₅₀	360.3 μM Compound: 2, d4A	Cytotoxicity against human CEM/0 cells Cytotoxicity against human CEM/0 cells	[PMID: 24411122]
CCRF-CEM	CC₅₀	91 μM Compound: 2[d4A]	Compound was evaluated for cytotoxic activity against CEM cells. Compound was evaluated for cytotoxic activity against CEM cells.	10.1016/0960-894X(96)00433-7
CCRF-CEM	CC₅₀	91 μM Compound: d4A	Compound was evaluated for its concentration (potency) to inhibit the growth of CEM cells. Compound was evaluated for its concentration (potency) to inhibit the growth of CEM cells.	[PMID: 10498207]
CCRF-CEM	CC₅₀	96 μM Compound: 3	In vitro cytotoxic concentration in CEM cells. In vitro cytotoxic concentration in CEM cells.	[PMID: 10229629]
CCRF-CEM	EC₅₀	0.54 μM Compound: 7 beta-Ld4A	Antiviral activity against HIV in CEM cell line Antiviral activity against HIV in CEM cell line	10.1016/0960-894X(96)00293-4
CCRF-CEM	EC₅₀	20 μM Compound: 2[d4A]	Compound was evaluated for antiviral activity against HIV-1 (IIIB) infected CEM cells. Compound was evaluated for antiviral activity against HIV-1 (IIIB) infected CEM cells.	10.1016/0960-894X(96)00433-7
CCRF-CEM	EC₅₀	20 μM Compound: 2[d4A]	Compound was evaluated for antiviral activity against HIV-2 (ROD) infected CEM cells. Compound was evaluated for antiviral activity against HIV-2 (ROD) infected CEM cells.	10.1016/0960-894X(96)00433-7
CCRF-CEM	EC₅₀	20 μM Compound: d4A	Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-1 in CEM cell culture. Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-1 in CEM cell culture.	[PMID: 10498207]
CCRF-CEM	EC₅₀	20 μM Compound: d4A	Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-2 in CEM cell culture. Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-2 in CEM cell culture.	[PMID: 10498207]
CCRF-CEM	IC₅₀	>=81.9 μM Compound: 2, d4A	Antiviral activity against HIV-2 ROD infected in thymidine kinase-deficient human CEM cells Antiviral activity against HIV-2 ROD infected in thymidine kinase-deficient human CEM cells	[PMID: 24411122]
CCRF-CEM	IC₅₀	37 μM Compound: 7 beta-Ld4A	Concentration required to inhibit 50% of CEM cell lines Concentration required to inhibit 50% of CEM cell lines	10.1016/0960-894X(96)00293-4
HepG2	EC₅₀	1.2 μM Compound: 7 beta-Ld4A	Antiviral activity against Hepatitis B virus in 2.2.15 cell line Antiviral activity against Hepatitis B virus in 2.2.15 cell line	10.1016/0960-894X(96)00293-4
HepG2	IC₅₀	70 μM Compound: 7 beta-Ld4A	Concentration required to inhibit 50% of 2.2.15 cell line Concentration required to inhibit 50% of 2.2.15 cell line	10.1016/0960-894X(96)00293-4
MT4	CC₅₀	277.5 μM Compound: 2, d4A	Cytotoxicity against human MT4 cells Cytotoxicity against human MT4 cells	[PMID: 24411122]
MT4	ED₅₀	>25 μM Compound: 18	Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction	[PMID: 3499515]
MT4	IC₅₀	>277.5 μM Compound: 2, d4A	Antiviral activity against HIV-1 3B infected in human MT4 cells Antiviral activity against HIV-1 3B infected in human MT4 cells	[PMID: 24411122]
MT4	IC₅₀	>277.5 μM Compound: 2, d4A	Antiviral activity against HIV-2 ROD infected in human MT4 cells Antiviral activity against HIV-2 ROD infected in human MT4 cells	[PMID: 24411122]

体外実験

beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. Results confirm that the biological activity of NSC 108602 is connected with the termination of the DNA chain synthesis in the 5′-3′ direction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 7057-48-9
性状 Solid
分子量 233.23
分子式 C₁₀H₁₁N₅O₂
SMILES

OC[C@@H](O1)C=C[C@@H]1N2C=NC3=C(N)N=CN=C32
別名

2'3'-didehydro-2'3'-dideoxyadenosine
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ponomareva AG, et al. Structural and energetic properties of the potential HIV-1 reverse transcriptase inhibitors d4A and d4G: a comprehensive theoretical investigation. J Biomol Struct Dyn. 2014;32(5):730-40. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

beta-L-D4A

Zidovudine

Obefazimod

Enfuvirtide

Fosamprenavir

Bevirimat

Fostemsavir

Fosamprenavir Calcium Salt

Zidovudine (Standard)

Temsavir

BMS-378806

Fostemsavir Tris

GSK2838232

HIV アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

beta-L-D4A

Zidovudine

Obefazimod

Enfuvirtide

Fosamprenavir

Bevirimat

Fostemsavir

Fosamprenavir Calcium Salt

Zidovudine (Standard)

Temsavir

BMS-378806

Fostemsavir Tris

GSK2838232

HIV アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

beta-L-D4A 関連分類

HY-100260 関連分類

Bioz