Olsalazine (Disodium)
Based on 2 publication(s) in Google Scholar
Olsalazine Disodium is an orally active prodrug of 5-ASA (HY-15027). Olsalazine Disodium can inhibit cells proliferation and induce apoptosis. Olsalazine Disodium can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine Disodium can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- CAS 番号: 6054-98-4
- 分子式: C14H8N2Na2O6
- 分子量:346.20
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Olsalazine Disodium
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生物活性
Olsalazine Disodium (0-30 μM, 48 h) reduces cell viability in canine lymphoid tumor cell[4].
Olsalazine Disodium (0.19-1.64 μM, 24 h) induces apoptosis in canine lymphoid tumor cell[4].
Olsalazine Disodium (0.03 μM, 48 h) increases 5-mC levels of genomic DNA in canine lymphoid tumor cell lines[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Olsalazine Disodium (50 mg/kg, p.o., daily for 11 days) ameliorates colitis companied with Cannabidiol in dextran sulphate sodium (DSS)-induced acute and chronic colitis mice models[2].
Olsalazine Disodium (5-20 mg/kg) decreases the levels of serum urate in hyperuricemic rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colorectal cancer rats models[1]
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Dosage:25 mg/kg
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Administration:Orally gavage, daily for 3 weeks
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Result:Reduced the numbers of ACF and tumors.
Increased apoptotic cells and inhibited proliferation of tumor.
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Animal Model:Dextran sulphate sodium (DSS)-induced acute and chronic colitis mice models[2]
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Dosage:50 mg/kg, companied with Cannabidiol (10 mg/kg)
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Administration:Orally administration, daily for 11 days
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Result:Reduced DAI, MPO activity, and inflammatory cytokines.
Restored colon length and GLP-1 levels.
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Animal Model:Hyperuricemic rats[3]
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Dosage:5, 10 and 20 mg/kg
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Administration:Intraperitoneally injection
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Result:Reduced the levels of serum urate.
Reduced GLUT9, OAT3, OAT1 and NPT1 levels.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 6054-98-4
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性状 Solid
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分子量 346.20
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分子式 C14H8N2Na2O6
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Color Light yellow to yellow
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SMILES
O=C(O[Na])C1=C(O)C=CC(/N=N/C2=CC(C(O[Na])=O)=C(O)C=C2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
溶剤 & 溶解度
H2O : 50 mg/mL (144.43 mM; Need ultrasonic)
DMSO : 20 mg/mL (57.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 15 mg/mL (43.33 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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参考文献
[1]. Brown WA, et al. 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci. 2000 Aug;45(8):1578-84. [Content Brief]
[2]. Thapa D, et al. Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis. Int J Mol Sci. 2025 Aug 16;26(16):7913. [Content Brief]
[3]. Niu Y, et al. Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals. Biol Pharm Bull. 2020 Nov 1;43(11):1653-1659. [Content Brief]
[4]. Itoh S, et al. Olsalazine inhibits cell proliferation and DNA methylation in canine lymphoid tumor cell lines. Pol J Vet Sci. 2021 Dec;24(4):515-523. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.8885 mL | 14.4425 mL | 28.8850 mL | 72.2126 mL |
| 5 mM | 0.5777 mL | 2.8885 mL | 5.7770 mL | 14.4425 mL | |
| 10 mM | 0.2889 mL | 1.4443 mL | 2.8885 mL | 7.2213 mL | |
| 15 mM | 0.1926 mL | 0.9628 mL | 1.9257 mL | 4.8142 mL | |
| 20 mM | 0.1444 mL | 0.7221 mL | 1.4443 mL | 3.6106 mL | |
| 25 mM | 0.1155 mL | 0.5777 mL | 1.1554 mL | 2.8885 mL | |
| 30 mM | 0.0963 mL | 0.4814 mL | 0.9628 mL | 2.4071 mL | |
| 40 mM | 0.0722 mL | 0.3611 mL | 0.7221 mL | 1.8053 mL | |
| 50 mM | 0.0578 mL | 0.2889 mL | 0.5777 mL | 1.4443 mL | |
| H2O | 60 mM | 0.0481 mL | 0.2407 mL | 0.4814 mL | 1.2035 mL |
| 80 mM | 0.0361 mL | 0.1805 mL | 0.3611 mL | 0.9027 mL | |
| 100 mM | 0.0289 mL | 0.1444 mL | 0.2889 mL | 0.7221 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Olsalazine Disodium 関連分類
HY-B0174 関連分類
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