TY-51469
Based on 1 publication(s) in Google Scholar
TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.79%
- CAS 番号: 603987-59-3
- 分子式: C20H15FN2O6S4
- 分子量:526.60
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 TY-51469
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生物活性
IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 603987-59-3
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性状 Solid
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分子量 526.60
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分子式 C20H15FN2O6S4
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Color Off-white to light brown
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SMILES
O=C(C1=CSC(C2=CC=C(NS(=O)(C3=C(C)C4=CC(F)=CC=C4S3)=O)C(S(=O)(C)=O)=C2)=N1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Immunol
Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability. [Abstract]2024 Nov 21:15:1477072. PMID: 39640264
溶剤 & 溶解度
DMSO : 33.33 mg/mL (63.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
Rats[1]
The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1].
Mice[1]
the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8990 mL | 9.4949 mL | 18.9897 mL | 47.4744 mL |
| 5 mM | 0.3798 mL | 1.8990 mL | 3.7979 mL | 9.4949 mL | |
| 10 mM | 0.1899 mL | 0.9495 mL | 1.8990 mL | 4.7474 mL | |
| 15 mM | 0.1266 mL | 0.6330 mL | 1.2660 mL | 3.1650 mL | |
| 20 mM | 0.0949 mL | 0.4747 mL | 0.9495 mL | 2.3737 mL | |
| 25 mM | 0.0760 mL | 0.3798 mL | 0.7596 mL | 1.8990 mL | |
| 30 mM | 0.0633 mL | 0.3165 mL | 0.6330 mL | 1.5825 mL | |
| 40 mM | 0.0475 mL | 0.2374 mL | 0.4747 mL | 1.1869 mL | |
| 50 mM | 0.0380 mL | 0.1899 mL | 0.3798 mL | 0.9495 mL | |
| 60 mM | 0.0316 mL | 0.1582 mL | 0.3165 mL | 0.7912 mL |
TY-51469 関連分類
HY-12370 関連分類
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