Complement System
The complement system, composed of more than 30 serum and cell surface components, is collaborating in recognition and elimination of pathogens as a part of both the innate and acquired immune systems. Once the complement system is activated, a chain of reactions involving proteolysis and assembly occurs, resulting in cleavage of the third complement component (C3). The cascade up to C3 cleavage is called the activation pathway. There are three activation pathways: the classical, lectin, and alternative pathways.
The complement cascade is a dual-edged sword, causing protection against bacterial and viral invasion by promoting phagocytosis and inflammation. Pathologically, complement can cause substantial damage to blood vessels (vasculitis), kidney basement membrane and attached endothelial and epithelial cells (nephritis), joint synovium (arthritis), and erythrocytes (hemolysis) if it is not adequately controlled.
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Complement System Inhibitors
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Complement System Agonists
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Complement System Antagonists
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Complement System Activators
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Complement System Modulator
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Complement System Controls
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Complement System Ligands
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Complement System Proteins
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Complement System 関連製品 (219)
関連製品 (219)
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組換えタンパク質 (112)
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抗体 (7)
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Cyclosporin A-OVA
0 Images製品番号: HY-NP194ACyclosporin A-OVA is a conjugate of Cyclosporin A (HY-B0579) and OVA. Cyclosporin A is an immunosuppressant which binds to the cyclophilin .
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Factor B-IN-3
0 Images製品番号: HY-147605CAS 番号: 2760669-74-5Factor B-IN-3 (Example 3 target compound) is a potent complement factor B inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity.
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GT103
0 Images製品番号: HY-P991954GT103 is a human-derived monoclonal antibody targeting complement factor H (CFH). GT103 binds to a conformationally distinct epitope of CFH on tumor cells. GT103 activates the classical complement pathway, induces complement-dependent cytotoxicity, and triggers antibody-dependent cellular phagocytosis (ADCP) of tumor cells. GT103 increases calreticulin translocation to tumor cell plasma membranes. GT103 mediates B-cell activation via Syk kinase phosphorylation. GT103 inhibits tumor growth and metastasis in animal models. GT103 can be used for the research of non-small cell lung cancer.
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Vensobafusp alfa
0 Images製品番号: HY-P991067CAS 番号: 2724922-85-2別名: KP-104Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)..
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Factor B-IN-2
0 Images製品番号: HY-147604CAS 番号: 2760669-72-3Factor B-IN-2 (Example 1 target compound) is a potent complement factor B inhibitor, with an IC50 of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity.
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Tubulin/NRP1-IN-1
0 Images製品番号: HY-163062CAS 番号: 2983719-82-8Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis.
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Cevolisiran sodium
0 Images製品番号: HY-177621ACevolisiran sodium, a siRNA, is a complement component 3 (C3) synthesis reducer.
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C5aR1 antagonist 2
0 Images製品番号: HY-163379CAS 番号: 2365161-92-6C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases.
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Avacincaptad pegol sodium scrambled negative control
0 Images製品番号: HY-147080BAvacincaptad pegol sodium scrambled negative control is the sequence scrambled negative control of Avacincaptad pegol sodium.
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Agazisiran sodium
0 Images製品番号: HY-177611AAgazisiran sodium, a siRNA,is a complement factor B synthesis reducer.
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3-O-(2'E,4'Z-Decadienoyl)ingenol
0 Images製品番号: HY-N7166CAS 番号: 84680-59-13-O-(2'E,4'Z-Decadienoyl)ingenol is a natural diterpene that exhibits significant anticomplement activity with an IC50 of 89.5 μM.
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Tarvicopan
0 Images製品番号: HY-172239CAS 番号: 2378381-06-5Tarvicopan is an inhibitor for complement factor D.
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Anti-CD88/C5AR1 Antibody (G2_anti-C5aR)
0 Images製品番号: HY-P991485Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) is a human monoclonal antibody (mAb) targeting C5AR1.
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Cevolisiran sodium scrambled negative control
0 Images製品番号: HY-177621BCevolisiran sodium scrambled negative control is the sequence scrambled negative control of Cevolisiran sodium.
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Dexamethasone-d5-1
0 Images製品番号: HY-14648S1別名: Hexadecadrol-d5-1; Prednisolone F-d5-1Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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Cevolisiran
0 Images製品番号: HY-177621CAS 番号: 3069641-77-3Cevolisiran, a siRNA, is a complement component 3 (C3) synthesis reducer.
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MEDI7814
0 Images製品番号: HY-P991657MEDI7814 is a humanized monoclonal antibody inhibitor targeting C5a and C5adesArg. MEDI7814 binds to recombinant human C5a and serum purified human C5a with affinities of 14 pM and 8 pM, respectively. MEDI7814 is acute inflammatory diseases such as sepsis and renal ischemia-reperfusion injury.
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Avacopan (Standard)
0 Images別名: CCX168 (Standard)Avacopan (Standard) is the analytical standard of Avacopan. This product is intended for research and analytical applications. Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC50 of 0.1 nM.
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Bisphenol A bissulfate disodium
0 Images製品番号: HY-W587516CAS 番号: 10040-44-5Bisphenol A bissulfate disodium is a metabolite of Bisphenol A (HY-18260). Bisphenol A bissulfate disodium (compound 7) show complement-inhibiting activity with an IC50 of 247 μM.
