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United States

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製品番号: HY-184146

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AD05

AD05 is a SARS-CoV-2 main protease (M^pro) inhibitor with an IC₅₀ of 306.5 nM. AD05 exhibits antiviral activity against wild-type SARS-CoV-2 in host cells without inducing significant cytotoxicity. AD05 can be used in studies related to SARS-CoV-2 infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₇H₂₃ClN₄O₄S
分子量:414.91

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AD05 構造式

容量

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

AD05 inhibits wild-type SARS-CoV-2 replication in Vero E6 cells with an EC₅₀ of 3.22 μM^[1].
AD05 shows no significant cytotoxicity in Vero E6 cells, with a CC₅₀ > 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 414.91
分子式 C₁₇H₂₃ClN₄O₄S
SMILES

CC(C[C@@H](C(N[C@@H](C[C@@H]1CCNC1=O)C=O)=O)NC(C2=CSC(Cl)=N2)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Yin W, et al. Design, Synthesis, and Evaluation of Novel Thiazole-Based Peptidomimetic Compounds as Potent SARS-CoV-2 Main Protease Covalent Inhibitors. ACS Infect Dis. 2026 Jun 12;12(6):1915-1923.
[Content Brief]

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モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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