ADI-15878
Based on 1 Customer Validation
ADI-15878 (ADI-15742; MBP-134 AF) is an Ebola virus GP-binding antibody. ADI-15878 blocks GP-mediated membrane fusion and viral entry by binding to a conserved, non-overlapping epitope comprising the GP1 N-terminal pocket and the GP2 fusion loop. As a component of MBP134, ADI-15878 targets an epitope conserved in BDBV sequences, supporting cross-species activity against EBOV and BDBV, and can be used in combination with ADI-15946 and/or CA45 for next-generation monoclonal antibody cocktail therapy. ADI-15878 can be used for research on Bundibugyo virus disease and Ebola virus disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.80%
- 分子量:144.82 kDa
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保管条件:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Virus
IC50 & Target
Envelope glycoprotein, GP2
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
0.48 μg/mL
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Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
| Huh-7 | IC50 |
0.01 μg/mL
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Neutralization of BDBV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
Neutralization of BDBV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
| Huh-7 | IC50 |
0.04 μg/mL
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Neutralization of SUDV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
Neutralization of SUDV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
| Huh-7 | IC50 |
0.29 μg/mL
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Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells in Frame-2 background assessed by luciferase activity 48 hrs post-transduction.
Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells in Frame-2 background assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
体外実験
ADI-15878 (50-0.016 µg/mL; 1 h at room temperature) binds to 293T cells expressing wild-type EBOV-GP, and at 10 ng/mL its binding to the G528E mutant decreases sharply, with only 1% of cells in the Q3 region[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
ELISA, FACS, Functional assay
化学情報
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性状 Liquid
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分子量 144.82 kDa
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Color Colorless to light yellow
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SMILES
[ADI-15878]
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別名
ADI-15742; MBP-134 AF
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ADI-15878 関連分類
HY-P991450 関連分類
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