ALK-IN-24
ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. ALK-IN-24 also inhibits insulin receptor kinase with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells. ALK-IN-24 inhibits ALK-driven tumor growth in xenograft mouse models. ALK-IN-24 can be used in research related to non-small cell lung cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2093414-37-8
- 分子式: C26H30ClN7O3S
- 分子量:556.08
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H3122 | TGI |
86.3 %
Compound: 29
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Antitumor activity against human NCI-H3122 cells xenografted in BALB/c nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg administered once daily via oral gavage for 14 days measured twice weekly during compound dosing relative to control
Antitumor activity against human NCI-H3122 cells xenografted in BALB/c nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg administered once daily via oral gavage for 14 days measured twice weekly during compound dosing relative to control
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[PMID: 28385505] |
ALK-IN-24 (Compound 6) inhibits wild-type ALK and ALKL1196M mutant kinases in the HTRF KinEASE-TK enzymatic assay, with IC50 values of 1.7 nM and 8.1 nM, respectively[1].
ALK-IN-24 inhibits insulin receptor kinase with an IC50 of 6.0 nM in the HTRF KinEASE-TK enzymatic activity assay[1].
ALK-IN-24 inhibits the proliferation of H3122 cells in cell-based proliferation assays, with a CC50 of 36 nM[1].
ALK-IN-24 inhibits the proliferation of BaF3 cells expressing ALKL1196M in cell-based proliferation assays, with a CC50 of 120 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (8 mice per group)[1]
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Dosage:50 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Achieved a tumor growth inhibition (TGI) rate of 86.3% during the 14-day treatment period.
Showed slow tumor regrowth after treatment discontinuation.
Caused no changes in body weight or side effects during the study.
化学情報
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CAS 番号 2093414-37-8
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分子量 556.08
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分子式 C26H30ClN7O3S
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SMILES
O=S(=O)(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC=3C=C4C(=CC3OC)N5C(=NN(C)CC5)CC4)C(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ALK-IN-24 関連分類
HY-153503 関連分類
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