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製品番号: HY-186234

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α-Synuclein aggregate binder 3

α-Synuclein aggregate binder 3 is a probe for α-synuclein aggregates. The K_i value of α-Synuclein aggregate binder 3 for binding to sonicated α-synuclein fibrils is 0.8 nM. α-Synuclein aggregate binder 3 can be used for α-synuclein imaging, as well as for detecting disorders associated with α-synuclein aggregation, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

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CAS 番号: 2648041-95-4
分子式: C₁₅H₁₃FN₄
分子量:268.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Synuclein aggregate binder 3 構造式

CAS 番号: 2648041-95-4

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

α-synuclein Aggregation

α-synuclein アイソフォーム固有の製品をすべて表示 :

体外実験

α-Synuclein aggregate binder 3 (compound 3) binds to sonicated α-synuclein fibrils with a K_i of 0.95 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 2648041-95-4
分子量 268.29
分子式 C₁₅H₁₃FN₄
SMILES

FC1=NC=CC(C2=CC(C3=CC=C(NC)C=C3)=NN2)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1].
Armin Giese, et al. Novel compounds for the diagnosis, treatment and prevention of diseases associated with the aggregation of alpha-synuclein. WO2021099518A1. 2020-11-19.

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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α-Synuclein aggregate binder 3

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α-Synuclein aggregate binder 3

α-synuclein アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

プロトコル

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs