AM4085
AM4085 is an orally active Antagonist for FmlH with an IC50 of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H21F4NO6
- 分子量:459.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Pharmacokinetic Analysis of AM4085 in C3H/HeN mice[1]
| route | Dose (mg/kg) | C0 (ng/mL) | Cmax (ng/mL) | T1/2 (h) | Vdss (L/kg) | CL (mL/min/kg) | Tlast (h) | AUC0-last (ng·h/mL) | AUC0-inf (ng·h/mL) | MRT0-last (h) | MRT0-inf (h) | AUCExtra (%) | AUMCExtra (%) | F (%) |
| iv | 3 | 4427 | - | 1.47 | 1.42 | 13.6 | 8.0 | 3662 | 3736 | 1.59 | 1.75 | 1.90 | 10.8 | - |
| po | 10 | - | 1483 | 1.92 | - | - | 8.0 | 6070 | 6564 | 3.18 | 3.75 | 7.55 | 21.6 | 52.7 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 459.39
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分子式 C21H21F4NO6
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SMILES
FC1=CC=C(C2=C(C(F)(F)F)C=CC=C2O[C@@H]3O[C@H](CO)[C@H](O)[C@@H](O)[C@H]3NC(C)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AM4085 関連分類
HY-163291 関連分類
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