AMY109
Based on 1 Customer Validation
AMY109 is an anti-human interleukin-8 (IL-8) monoclonal antibody, with a Ka of 36.8 pM for human IL-8, and a Ka of 380 pM for cynomolgus monkey IL-8. AMY109 binds to human and cynomolgus monkey IL-8 in a pH-dependent manner, inhibits IL-8-mediated activation of CXCR1 and CXCR2, and blocks the downstream biological activities of IL-8. AMY109 inhibits neutrophil recruitment to endometriotic lesions and suppresses monocyte chemoattractant protein-1 production by neutrophils. AMY109 is applicable to research related to endometriosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 96.04%
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Species Reactivity
Human
体外実験
AMY109 (pH 7.4; pH 5.8) exhibits high binding affinity to human IL-8 and weaker but measurable binding affinity to cynomolgus monkey IL-8 under neutral conditions, with pH-dependent dissociation from human IL-8 at endosomal pH[1].
AMY109 potently neutralizes IL-8-dependent activation of both CXCR1 and CXCR2 in cell-based assays[1].
AMY109 (600 ng/mL IL-8) effectively inhibits IL-8-induced chemotaxis of both human and cynomolgus monkey neutrophils[1].
AMY109 inhibits both IL-8-induced human neutrophil migration and IL-8-stimulated MCP-1 production by human neutrophils[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Macaca fascicularis (female, reproductive age 8 to 14 years old, surgically induced endometriosis)[1]
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Dosage:2 mg/kg (maintenance dose; preceded by a 3 mg/kg loading dose); 10 mg/kg
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Administration:subcutaneous injection; every 4 weeks; 6 months
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Result:Maintained modified r-ASRM score stable, while it significantly increased in vehicle-treated monkeys.
Reduced relative volume of nodular lesions.
Induced atrophy of endometrial epithelium in 55% of evaluable sites (2 mg/kg) and 54% of evaluable sites (10 mg/kg).
Induced atrophy/decreased stromal cells in 33% of evaluable sites (2 mg/kg) and 60% of evaluable sites (10 mg/kg).
Decreased fibrotic interstitium in 34% of evaluable sites (2 mg/kg) and 61% of evaluable sites (10 mg/kg).
Reduced hemosiderin deposition compared to vehicle.
Produced marked reduction in postsurgical incision adhesions in 6 of 7 monkeys treated with 10 mg/kg.
Achieved greater lesion volume reduction in monkeys without antidrug antibodies (ADAs) than those with ADAs.
遺伝子ID
アクセッション番号
Target
CXCL8/IL-8
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
ELISA, FACS, Functional assay
化学情報
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[AMY109]
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AMY109 関連分類
HY-P992035 関連分類
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