CXCL8 - C-X-C motif chemokine ligand 8 Gene
Also Known as IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8
Species: Homo sapiens
About CXCL8
This gene has 5 transcripts (splice variants), 179 orthologues and 12 paralogues. Biased expression in bone marrow (RPKM 1065.5), appendix (RPKM 118.0) and 2 other tissues.
Summary
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of Infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with Other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract Infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and Other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]
CXCL8 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001354840.3 | NP_001341769.1 | interleukin-8 isoform 2 precursor |
| NM_000584.4 | NP_000575.1 | interleukin-8 isoform 1 precursor |
| NM_000584.4 | NP_000575.1 | interleukin-8 isoform 1 precursor |
| NM_001354840.3 | NP_001341769.1 | interleukin-8 isoform 2 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chemokine activity |
IDA
IDA: Inferred from direct assay
|
8399143 | GOA |
| enables heparin binding |
IDA
IDA: Inferred from direct assay
|
24501198 | GOA |
| enables interleukin-8 receptor binding |
IPI
IPI: Inferred from physical interaction
|
1840701 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10880251 | GOA |
CXCL8 Protein Structure
IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 91)
- 0
- 99 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interleukin-8 |
|
|
CXCL8 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CXCL8 | P10145 | TNFAIP6 | Homo sapiens | P98066 | 24501198 | |
|
Intra
|
CXCL8 | P10145 | TNFAIP6 | Homo sapiens | P98066 | 24501198 | |
|
Intra
|
CXCL8 | P10145 | PF4 | Homo sapiens | P02776 | 28381538 | |
|
Cross
|
CXCL8 | P10145 | ahcY | Mycobacterium tuberculosis | P9WGV3 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | ahcY | Mycobacterium tuberculosis | P9WGV3 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | ahcY | Mycobacterium tuberculosis | P9WGV3 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | glmU | Mycobacterium tuberculosis | P9WMN3 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | glmU | Mycobacterium tuberculosis | P9WMN3 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | glmU | Mycobacterium tuberculosis | P9WMN3 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | atsG | Mycobacterium tuberculosis | Q6MX51 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | atsG | Mycobacterium tuberculosis | Q6MX51 | 26829648 | |
|
Cross
|
CXCL8 | P10145 | atsG | Mycobacterium tuberculosis | Q6MX51 | 26829648 |
Recombinant CXCL8 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7224 | IL-8/CXCL8 Protein, Human | P10145 (A23-S99) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7379 | IL-8/CXCL8 Protein, Human (CHO) | P10145 (A23-S99) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7380 | IL-8/CXCL8 Protein, Human (72a.a) | P10145 (S28-S99) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70569 | IL-8/CXCL8 Protein, Human (HEK293, His) | P10145 (E21-S99) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73874 | IL-8/CXCL8 Protein, Human (72a.a, HEK293, His) | P10145 (S28-S99) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P73875 | IL-8/CXCL8 Protein, Human (HEK293, Fc) | P10145/NP_000575.1 (S28-S99) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78888 | IL-8/CXCL8 Protein, Human (Biotinylated, HEK293, His-Avi) | P10145 (S28-S99) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P700133AF | Animal-Free IL-8/CXCL8 Protein, Human (His) | P10145 (S28-S99) | ≥ 95%, as determined by reducing SDS-PAGE. |
CXCL8 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81106 | IL-8/CXCL8 Antibody | ELISA, IHC-P, IHC-F, ICC/IF | Human, Rabbit |
| HY-P81106A | IL-8/CXCL8 Antibody (PBS only) | ELISA, IHC-P, IHC-F, ICC/IF | Human, Rabbit |
| HY-P85498 | IL-8/CXCL8 Antibody (YA5190) | WB, ELISA | Human |
| HY-P85756 | IL-8/CXCL8 Antibody (YA5448) | IHC-P, ICC/IF | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Muscular Dystrophy |
|
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| Pyoderma Gangrenosum |
|
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| Hemolytic-Uremic Syndrome |
|
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| Neurosyphilis |
|
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| Macular Retinal Edema |
|
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| Churg-Strauss Syndrome |
|
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| Fibromyalgia |
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| Melanoma |
|
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| Dry Eye Syndrome |
|
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| Tracheitis |
|
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| Patent Ductus Arteriosus 1 |
|
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| Pyoderma |
|
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| Acne |
|
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| Endometriosis |
|
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| Chancroid |
|
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| Post-Cardiac Arrest Syndrome |
|
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| Autosomal Genetic Disease |
|
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| Periodontitis |
|
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| Vasculitis |
|
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| Malaria |
|
|
| Papillary Conjunctivitis |
|
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| Noma |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
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| Alcoholic Liver Cirrhosis |
|
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| Pulmonary Artery Disease |
|
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| Occupational Asthma |
|
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| Disease By Infectious Agent |
|
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| Cataract |
|
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| Central Nervous System Vasculitis |
|
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| Interstitial Lung Disease |
|
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| Dengue Disease |
|
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| Pemphigoid |
|
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| Acute Asthma |
|
|
| Bone Inflammation Disease |
|
|
| Leptospirosis |
|
|
| Corneal Disease |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Mycobacterium Kansasii |
|
|
| Acute Pyelonephritis |
|
|
| Headache |
|
|
| Blood Platelet Disease |
|
|
| Denture Stomatitis |
|
|
| Erythema Nodosum |
|
|
| Atherosclerosis Susceptibility |
|
|
| Breast Adenocarcinoma |
|
|
| Varicose Veins |
|
|
| Cecal Disease |
|
|
| Pulmonary Alveolar Proteinosis |
|
|
| Trichomoniasis |
|
|
| Colorectal Cancer |
|
|
| Bronchopneumonia |
|
|
| Lymph Node Disease |
|
|
| Cryptogenic Organizing Pneumonia |
|
|
| Erythema Elevatum Diutinum |
|
|
| Mycoplasma Pneumoniae Pneumonia |
|
|
| Sebaceous Gland Disease |
|
|
| Thrombocytopenia |
|
|
| Connective Tissue Disease |
|
|
| Lung Mucoepidermoid Carcinoma |
|
|
| Fasciitis |
|
|
| Retinal Vascular Disease |
|
|
| Myelitis |
|
|
| Burning Mouth Syndrome |
|
|
| Conjunctivitis |
|
|
| Pericarditis |
|
|
| Inflammatory Bowel Disease |
|
|
| Peripheral Vascular Disease |
|
|
| Pulmonary Eosinophilia |
|
|
| Acute Gonococcal Prostatitis |
|
|
| Critical Covid-19 |
|
|
| Necrotizing Ulcerative Gingivitis |
|
|
| Irritable Bowel Syndrome |
|
|
| Decubitus Ulcer |
|
|
| Placenta Disease |
|
|
| Allergic Asthma |
|
|
| Acute Generalized Exanthematous Pustulosis |
|
|
| Pharyngitis |
|
|
| Epidermolysis Bullosa |
|
|
| Cerebral Palsy |
|
|
| Apnea, Obstructive Sleep |
|
|
| Persistent Mild Asthma |
|
|
| Giant Papillary Conjunctivitis |
|
|
| Urticaria |
|
|
| Rheumatoid Arthritis |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Myocarditis |
|
|
| African Tick-Bite Fever |
|
|
| Severe Covid-19 |
|
|
| Vulvovaginitis |
|
|
| Baritosis |
|
|
| Purpura |
|
|
| Allergic Bronchopulmonary Aspergillosis |
|
|
| Vein Disease |
|
|
| Gastroesophageal Reflux |
|
|
| Pulmonary Edema |
|
|
| Bronchopulmonary Dysplasia |
|
|
| Trypanosomiasis |
|
|
| Newborn Respiratory Distress Syndrome |
|
|
| Acute Gonococcal Cervicitis |
|
|
| Systemic Scleroderma |
|
|
| Perinatal Necrotizing Enterocolitis |
|
|
| Paine Syndrome |
|
|
| Progressive Myoclonus Epilepsy 8 |
|
|
| Iridocyclitis |
|
|
| Chlamydia |
|
|
| Cystitis |
|
|
| Leprosy 3 |
|
|
| Retinitis Pigmentosa |
|
|
| Salmonellosis |
|
|
| Aseptic Meningitis |
|
|
| Covid-19 |
|
|
| Dermatitis, Atopic, 7 |
|
|
| Radiculopathy |
|
|
| Retinal Vascular Occlusion |
|
|
| Vaginal Discharge |
|
|
| Pleurisy |
|
|
| Toxicodendron Dermatitis |
|
|
| Cholesteatoma Of External Ear |
|
|
| Hepatic Veno-Occlusive Disease |
|
|
| Carotid Stenosis |
|
|
| Endometritis |
|
|
| Bronchitis |
|
|
| Toxic Shock Syndrome |
|
|
| Lung Giant Cell Carcinoma |
|
|
| Fallopian Tube Disease |
|
|
| Allergic Contact Dermatitis |
|
|
| Encephalomalacia |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Appendicitis |
|
|
| Acute Pericementitis |
|
|
| Middle Ear Disease |
|
|
| Nervous System Disease |
|
|
| Cholera |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Septic Arthritis |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Interstitial Lung Disease 2 |
|
|
| Vaginitis |
|
|
| Medulloblastoma |
|
|
| Pleural Tuberculosis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Lymphangioma |
|
|
| Ulcerative Colitis |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Anxiety |
|
|
| Respiratory Allergy |
|
|
| Dental Pulp Disease |
|
|
| Bladder Cancer |
|
|
| Aspiration Pneumonia |
|
|
| Rectal Disease |
|
|
| Mycobacterium Chelonae |
|
|
| Allergic Conjunctivitis |
|
|
| Esophageal Cancer |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Diabetic Macular Edema |
|
|
| Peptic Esophagitis |
|
|
| Pasteurellosis |
|
|
| Somatoform Disorder |
|
|
| Shigellosis |
|
|
| Poems Syndrome |
|
|
| Glycogen Storage Disease |
|
|
| Dermatitis, Atopic |
|
|
| Bronchiolitis Obliterans |
|
|
| Urinary Tract Infection |
|
|
| Exercise-Induced Bronchoconstriction |
|
|
| Lymphadenitis |
|
|
| Cowpox |
|
|
| Blood Coagulation Disease |
|
|
| Rosacea |
|
|
| Enterocolitis |
|
|
| Vaginal Disease |
|
|
| Prostatitis |
|
|
| Suppurative Periapical Periodontitis |
|
|
| Esophagitis |
|
|
| Bacterial Meningitis |
|
|
| Allergic Disease |
|
|
| Macular Holes |
|
|
| Laryngitis |
|
|
| Meningitis |
|
|
| Funisitis |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Cellulitis |
|
|
| Hydronephrosis |
|
|
| Aphthous Stomatitis |
|
|
| Adenoid Hypertrophy |
|
|
| Pulpitis |
|
|
| Cystic Fibrosis |
|
|
| Visceral Leishmaniasis |
|
|
| Sleep Disorder |
|
|
| Lymphocytic Choriomeningitis |
|
|
| Anthracosis |
|
|
| Sapho Syndrome |
|
|
| Cervicitis |
|
|
| Dermatitis |
|
|
| Leukostasis |
|
|
| Nasal Cavity Disease |
|
|
| Mastitis |
|
|
| Bacterial Vaginosis |
|
|
| Exudative Vitreoretinopathy 1 |
|
|
| Myelofibrosis |
|
|
| Stomatitis |
|
|
| Viral Meningitis |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Sudden Infant Death Syndrome |
|
|
| Mycetoma |
|
|
| Opportunistic Mycosis |
|
|
| Myocardial Infarction |
|
|
| Endophthalmitis |
|
|
| Amebiasis |
|
|
| Gingival Overgrowth |
|
|
| Erythema Multiforme |
|
|
| Temporal Arteritis |
|
|
| Silicosis |
|
|
| Peripheral Nervous System Disease |
|
|
| Arthritis |
|
|
| Intrinsic Asthma |
|
|
| Microvascular Complications Of Diabetes 1 |
|
|
| Pulmonary Emphysema |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Retinal Detachment |
|
|
| Contact Blepharoconjunctivitis |
|
|
| Schizophrenia |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Monocytic Leukemia |
|
|
| Leukemia, Acute Monocytic |
|
|
| Vernal Keratoconjunctivitis |
|
|
| Infective Endocarditis |
|
|
| Asthma |
|
|
| Contact Dermatitis |
|
|
| Pneumonia |
|
|
| Spondyloarthropathy |
|
|
| Pancreatic Cancer |
|
|
| Leukemia, Acute Myeloid |
|
|
| Acquired Metabolic Disease |
|
|
| Meconium Aspiration Syndrome |
|
|
| Blepharitis |
|
|
| Urethritis |
|
|
| Endometrial Disease |
|
|
| Environmental Induced Asthma |
|
|
| Synovitis |
|
|
| Dysentery |
|
|
| Brucellosis |
|
|
| Dermatitis Herpetiformis |
|
|
| Leishmaniasis |
|
|
| Peritonitis |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Lung Disease |
|
|
| Osteoarthritis |
|
|
| Alcoholic Hepatitis |
|
|
| Paracoccidioidomycosis |
|
|
| Mumps |
|
|
| Trichuriasis |
|
|
| Chronic Asthma |
|
|
| Coccidiosis |
|
|
| Myasthenic Syndrome, Congenital, 2a, Slow-Channel |
|
|
| Epididymis Disease |
|
|
| Coronavirus Infectious Disease |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Keratitis, Hereditary |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Behcet Syndrome |
|
|
| Non-Severe Covid-19 |
|
|
| Periapical Granuloma |
|
|
| Retinal Vein Occlusion |
|
|
| Inflammatory Diarrhea |
|
|
| Viral Pneumonia |
|
|
| Hyperuricemia |
|
|
| Keratopathy |
|
|
| Uveal Disease |
|
|
| Neuritis |
|
|
| Uveitis |
|
|
| Leukocyte Disease |
|
|
| Idiopathic Interstitial Pneumonia |
|
|
| Bacteriuria |
|
|
| Celiac Disease 1 |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Plasma Protein Metabolism Disease |
|
|
| Optic Neuritis |
|
|
| Endocarditis |
|
|
| Intracranial Berry Aneurysm |
|
|
| Atrophic Gastritis |
|
|
| Chronic Conjunctivitis |
|
|
| Mycobacterium Marinum |
|
|
| Necrotizing Fasciitis |
|
|
| Diarrhea |
|
|
| Gout |
|
|
| Tonsillitis |
|
|
| Aggressive Periodontitis |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Sensory System Disease |
|
|
| Breast Cancer |
|
|
| Blood Group, Globoside System |
|
|
| Exanthem |
|
|
| Lichen Disease |
|
|
| Bronchiectasis |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Pleural Disease |
|
|
| Bacterial Infectious Disease |
|
|
| Gastritis |
|
|
| Periapical Periodontitis |
|
|
| Urethral Syndrome |
|
|
| Bronchiolitis |
|
|
| Common Cold |
|
|
| Pericardium Disease |
|
|
| Chagas Disease |
|
|
| Lacrimal Apparatus Disease |
|
|
| Primary Biliary Cholangitis |
|
|
| Gastric Cancer |
|
|
| Gastroenteritis |
|
|
| Intracranial Abscess |
|
|
| Gingivitis |
|
|
| Long Covid |
|
|
| Clonorchiasis |
|
|
| Skin Disease |
|
|
| Acute Necrotizing Pancreatitis |
|
|
| Neutrophilic Dermatosis, Acute Febrile |
|
|
| Vesicoureteral Reflux |
|
|
| Intermittent Asthma |
|
|
| Osteoporosis |
|
|
| Dengue Hemorrhagic Fever |
|
|
| Aspiration Pneumonitis |
|
|
| Bacillary Angiomatosis |
|
|
| Avian Influenza |
|
|
| Candidiasis |
|
|
| Placental Insufficiency |
|
|
| Retinal Artery Occlusion |
|
|
| Neuroblastoma |
|
|
| Colonic Benign Neoplasm |
|
|
| Tracheal Disease |
|
|
| Chronic Ulcer Of Skin |
|
|
| Pre-Eclampsia |
|
|
| Chronic Fatigue Syndrome |
|
|
| Seborrheic Dermatitis |
|
|
| Human Granulocytic Anaplasmosis |
|
|
| Endocardium Disease |
|
|
| Psoriasis |
|
|
| Fuchs' Heterochromic Uveitis |
|
|
| Pulmonary Fibrosis |
|
|
| Adult Respiratory Distress Syndrome |
|
|
| Dengue Shock Syndrome |
|
|
| Hellp Syndrome |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Duodenal Ulcer |
|
|
| Bacterial Conjunctivitis |
|
|
| Preterm Premature Rupture Of The Membranes |
|
|
| Croup |
|
|
| Pneumoconiosis |
|
|
| Acute Cervicitis |
|
|
| Status Asthmaticus |
|
|
| Osteomyelitis |
|
|
| Parasitic Ectoparasitic Infectious Disease |
|
|
| Allergic Rhinitis |
|
|
| Lichen Planus |
|
|
| Multiple Sclerosis |
|
|
| Paranasal Sinus Disease |
|
|
| Psoriatic Arthritis |
|
|
| Capillary Leak Syndrome |
|
|
| Periventricular Leukomalacia |
|
|
| Aortic Aneurysm |
|
|
| Haemophilus Influenzae |
|
|
| Aspergillosis |
|
|
| Pustulosis Of Palm And Sole |
|
|
| Back Pain |
|
|
| Constipation |
|
|
| Neovascular Glaucoma |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Primary Ciliary Dyskinesia |
|
|
| Senile Entropion |
|
|
| Hepatitis B |
|
|
| Bronchial Disease |
|
|
| T2-Low Asthma |
|
|
| Cholangitis |
|
|
| Salpingitis |
|
|
| Hypertension, Essential |
|
|
| Crohn'S Disease |
|
|
| Extrinsic Allergic Alveolitis |
|
|
| Swine Influenza |
|
|
| Vitreous Disease |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Ovarian Cancer |
|
|
| Chorioamnionitis |
|
|
| Hyperostosis |
|
|
| Rhinitis |
|
|
| Fungal Infectious Disease |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
|
| Ovarian Hyperstimulation Syndrome |
|
|
| Colitis |
|
|
| Background Diabetic Retinopathy |
|
|
| Lens Disease |
|
|
| Pyelonephritis |
|
|
| Diabetes Mellitus |
|
|
| Respiratory Failure |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Otitis Media |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Bacterial Pneumonia |
|
|
| Familial Mediterranean Fever |
|
|
| Nose Disease |
|
|
| Dilated Cardiomyopathy |
|
|
| Bacterial Sepsis |
|
|
| Sleep Apnea |
|
|
| Gingival Disease |
|
|
| Viral Infectious Disease |
|
|
| Acute Diarrhea |
|
|
| Pyelitis |
|
|
| Alpha-1-Antitrypsin Deficiency |
|
|
| Pancreatitis |
|
|
| Eye Disease |
|
|
| Peptic Ulcer Disease |
|
|
| Hypereosinophilic Syndrome |
|
|
| Neutropenia |
|
|
| Chondroblastoma |
|
|
| Irritant Dermatitis |
|
|
| Opisthorchiasis |
|
|
| Excessive Tearing |
|
|
| Integumentary System Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Conjunctival Disease |
|
|
| Hepatocellular Carcinoma |
|
|