TNFAIP6 - TNF alpha induced protein 6 Gene

Also Known as TSG6; TSG-6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7130

About TNFAIP6

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:151,357,592-151,381,340 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 2 paralogues. Biased expression in appendix (RPKM 17.8), gall bladder (RPKM 12.0) and 11 other tissues.

Summary

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

TNFAIP6 Products (2)

mRNA	Protein	Name
NM_007115.4	NP_009046.2	tumor necrosis factor-inducible gene 6 protein precursor
NM_007115.4	NP_009046.2	tumor necrosis factor-inducible gene 6 protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	26468290	GOA
enables carboxylesterase activity	IDA IDA: Inferred from direct assay	16873769	GOA
enables fibronectin binding	IDA IDA: Inferred from direct assay	18042364	GOA
enables hyaluronic acid binding	IDA IDA: Inferred from direct assay	26468290	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16771708	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fibronectin fibril organization	IDA IDA: Inferred from direct assay	18042364	GOA
involved in hyaluronan metabolic process	IDA IDA: Inferred from direct assay	20463016	GOA
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	16771708	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	21569482	GOA
involved in negative regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	24501198	GOA
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	16771708	GOA
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	18586671	GOA
involved in positive regulation of receptor clustering	IDA IDA: Inferred from direct assay	26823460	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	1730767	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP6 Protein Structure

Xlink

CUB

0
100
200
277 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor-inducible gene 6 protein	TNF-stimulated gene 6 protein

TNFAIP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFAIP6	P98066	PTX3	Homo sapiens	P26022	SPR	22267482
Intra	TNFAIP6	P98066	PTX3	Homo sapiens	P26022	ELISA	22267482
Intra	TNFAIP6	P98066	Q6KF10-PRO_0000042253	Homo sapiens	Q6KF10-PRO_0000042253	ELISA	18586671
Intra	TNFAIP6	P98066	Q6KF10-PRO_0000042253	Homo sapiens	Q6KF10-PRO_0000042253	SPR	18586671
Intra	TNFAIP6	P98066	P43026-PRO_0000033913	Homo sapiens	P43026-PRO_0000033913	SPR	18586671
Intra	TNFAIP6	P98066	P43026-PRO_0000033913	Homo sapiens	P43026-PRO_0000033913	ELISA	18586671
Intra	TNFAIP6	P98066	O14625-PRO_0000005106	Homo sapiens	O14625-PRO_0000005106	SPR	27044744
Intra	TNFAIP6	P98066	P13500-PRO_0000005146	Homo sapiens	P13500-PRO_0000005146	SPR	27044744
Intra	TNFAIP6	P98066	P80098-PRO_0000005183	Homo sapiens	P80098-PRO_0000005183	SPR	27044744
Intra	TNFAIP6	P98066	Q99731-PRO_0000005214	Homo sapiens	Q99731-PRO_0000005214	SPR	27044744
Intra	TNFAIP6	P98066	FN1	Homo sapiens	P02751	Crosslink	18042364
Intra	TNFAIP6	P98066	FN1	Homo sapiens	P02751	Solid Phase Assay	18042364
Intra	TNFAIP6	P98066	CXCL8	Homo sapiens	P10145	SPR	24501198
Intra	TNFAIP6	P98066	CXCL8	Homo sapiens	P10145	ELISA	24501198
Intra	TNFAIP6	P98066	TNFSF11	Homo sapiens	O14788	SPR	18586671
Intra	TNFAIP6	P98066	TNFSF11	Homo sapiens	O14788	ELISA	18586671
Intra	TNFAIP6	P98066	P12643-PRO_0000033825	Homo sapiens	P12643-PRO_0000033825	ELISA	18586671
Intra	TNFAIP6	P98066	P12643-PRO_0000033825	Homo sapiens	P12643-PRO_0000033825	SPR	18586671

Cross: Cross-species interaction Intra: Intraspecies interaction

TNFAIP6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810936	TSG6 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89884	TSG-6 Antibody (YA9228)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Mucopolysaccharidosis, Type Ix	Mucopolysaccharidosis Type Ix Hyaluronidase Deficiency MPS9 Mps Ix Mucopolysaccharidosis Ix Mpsix Mucopolysaccharidosis Type 9 Mucopolysaccharidosis 9
Anal Fistula	Anorectal Fistula Rectal Fistula Allingham Ulcer Perianal Fistula Fistula In Ano Anorectum Fistula

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14790	TNFAIP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19097	Tnfaip6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25586	Tnfaip6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNFAIP6	RGD	RGD:621359
Felis catus	TNFAIP6	VGNC	VGNC:66399
Mus musculus	TNFAIP6	MGD	MGI:1195266
Canis familiaris	TNFAIP6	VGNC	VGNC:47651
Bos taurus	TNFAIP6	VGNC	VGNC:36156
Macaca mulatta	TNFAIP6	VGNC	VGNC:78581
Others	TNFAIP6	NCBI