Anticancer agent 329
Anticancer agent 329 is a mitochondria-targeted Podophyllotoxin (HY-15552) derivative conjugated with F16 (HY-100395), and also acts as an anticancer agent. Anticancer agent 329 accumulates in mitochondria and induces Apoptosis in a concentration-dependent manner. Anticancer agent 329 can be used in the research of liver cancer, colorectal cancer, non-small cell lung cancer and breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3128226-38-7
- 分子式: C45H47BrN2O9
- 分子量:839.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Anticancer agent 329 (Compound 6d) potently inhibits the proliferation of HepG2, HCT116, A549, and MDA-MB-231 cells with IC50 values of 0.66 μM, 1.10 μM, 2.00 μM, and 3.31 μM respectively, and exhibits a selectivity index of 2.29 for HepG2 cells over normal QSG-7701 hepatocytes[1].
Anticancer agent 329 (1.2-4.8 μM; 24 h) induces apoptosis in HepG2 cells in a concentration-dependent manner, with total apoptosis rates reaching 17.79% at a 4.8 μM 24-hour treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3128226-38-7
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分子量 839.77
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分子式 C45H47BrN2O9
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SMILES
O=C(OC1)[C@@H]([C@H]1[C@H]2OC(CCCCCCC[N+]3=CC=C(/C=C/C4=CNC5=C4C=CC=C5)C=C3)=O)[C@H](C6=CC(OC)=C(OC)C(OC)=C6)C(C2=C7)=CC8=C7OCO8.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 329 関連分類
HY-184280 関連分類
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