Antitumor agent-145
Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2983120-65-4
- 分子式: C44H34IrN5OS
- 分子量:873.06
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Antitumor agent-145 (Compound Ir5) (48 h) could effectively reduce the cell viability of BEL-7402/DDP cells with IC50 value of 0.49 μM and a resistance coefficient (RF) of 1.04. No obvious cytotoxicity Antitumor agent-145[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Antitumor agent-145 (1.5 or 3.0 mg/kg, intravenous injection, every other day for 21 days) BEL-7402/DDP tumor xenograft models can significantly inhibit the growth and metastasis of CDDP resistant tumors without causing obvious tissue damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice
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Dosage:NaCl, CDDP (3 mg/kg), Ir5 (1.5 mg/kg), and Ir5 (3 mg/kg)
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Administration:every other day for 21 days
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Result:The tumor volume in BALB/c mice was significantly reduced, and there was no significant difference in the weight of major organs.
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Animal Model:BEL-7402/DDP tumor xenograft models
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Dosage:1.5 mg/kg or 3 mg/kg
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Administration:every 2 days for 21 days
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Result:The results revealed that Ir5 significantly decreases the tumor volume, with an inhibition rate of tumor growth (IRT) of 40.0% at a dose of 1.5 mg/kg and 58.1% at a dose of 3 mg/kg, compared to only 10.1% in the CDDP group. No obvious tissue injury.
化学情報
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CAS 番号 2983120-65-4
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分子量 873.06
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分子式 C44H34IrN5OS
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SMILES
OC1=C(C2=CC=CC=C2C=C1)/C=[N]3N=C(N(C)C)[S-][Ir+3]\345([N]6=C(C7=C(C=C6)C=CC=C7)C8=CC=CC=[C-]85)[N]9=C(C%10=C(C=C9)C=CC=C%10)C%11=CC=CC=[C-]%114
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (284 KB)
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SDS (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-145 関連分類
HY-162348 関連分類
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