Apoptosis inducer 62
Apoptosis inducer 62 is an apoptosis inducer that reduces the expression levels of anti-apoptotic proteins Bcl-2 and Bcl-xL. Apoptosis inducer 62 induces ROS accumulation, mitochondrial membrane potential depolarization, DNA damage, cell cycle arrest. Apoptosis inducer 62 exhibits activity in colorectal tumor xenograft models. Apoptosis inducer 62 can be used for research related to colorectal cancer.
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- 分子式: C36H42F3NO3
- 分子量:593.72
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
Bcl-xL |
Bcl-2 |
体外実験
Apoptosis inducer 62 (Compound 28a) (1 μM; 72 h) potently inhibits the proliferation of HCT116, MIA-PaCa-2, HepG-2 and HeLa cancer cells, with IC50 values of 0.34, 0.6, 0.71 and 0.77 μM[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) significantly increases intracellular ROS levels in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) induces mitochondrial membrane potential depolarization in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) significantly induces apoptosis in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) induces S-phase cell cycle arrest in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.25-1 μM; 24 h) regulates the expression of apoptosis-related proteins and DNA damage-related proteins (Bcl-xL, Bcl-2, Cyt c, γ-H2AX) in HCT116 cells, and promotes cell apoptosis and DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.5, 1 and 2 μM
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Incubation Time:48 h
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Result:Significantly induced apoptosis in HCT116 cells in a concentration-dependent manner.
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Cell Line:HCT116 cells
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Concentration:0.5, 1 and 2 μM
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Incubation Time:48 h
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Result:Significantly induced S-phase cell cycle arrest in HCT116 cells in a concentration-dependent manner.
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Cell Line:HCT116 cells
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Concentration:0.25, 0.5 and 1 μM
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Incubation Time:24 h
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Result:Decreased Bcl-xL and Bcl-2.
Increased Cyt c and γ-H2AX.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (female, 5 weeks old)[1]
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Dosage:2 mg/kg
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Administration:i.p.; daily; 14 days
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Result:Achieved a tumor growth inhibition rate (TGI) of 47.9%.
Significantly suppressed tumor volume and tumor weight compared to the control group.
Caused no obvious body weight loss during the 14-day treatment period.
化学情報
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分子量 593.72
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分子式 C36H42F3NO3
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SMILES
O=C1C=C2[C@]3(C)CC[C@@]4(C)[C@]5([H])C[C@@](C(N)=O)(CC6=CC=C(C(F)(F)F)C=C6)CC[C@]5(C)CC[C@]4(C)C3=CC=C2C(C)=C1O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 62 関連分類
HY-184302 関連分類
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Keywords
- Apoptosis inducer 62
- Apoptosis inducer62
- Apoptosis inducer-62
- Apoptosis
- Bcl-2 Family
- Reactive Oxygen Species (ROS)
- DNA/RNA Synthesis
- colorectal tumor xenograft model
- Bcl-2
- mitochondrial membrane potential depolarization
- γ-H2AX
- Bcl-xL
- reactive oxygen species
- apoptosis
- colorectal cancer cells
- cell cycle arrest
- HCT116
- Inhibitor
- inhibitor
- inhibit