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製品番号: HY-178672

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ARCA

Name: ARCA
Brand: MedChemExpress
SKU: HY-178672
Availability: PreOrder

(別名: Anti-Reverse cap analog; m2 7,3′O GpppG)

ARCA (Anti-Reverse cap analog; m₂^7,3'OGpppG) is a 5′-cap analog. ARCA carries a methyl group at the 3'-OH position of m7G, which ensures that the cap is ligated to the 5' end of mRNA in the correct orientation during in vitro transcription and prevents reverse ligation. ARCA enhances the translation efficiency and stability of mRNA. In human immature dendritic cells, both the translation efficiency and total protein expression of ARCA-capped mRNA are higher than those of conventional m7GpppG-capped mRNA. ARCA can be used in research related to cancer, infectious diseases and mRNA vaccines.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 400806-46-4
分子式: C₂₂H₃₁N₁₀O₁₈P₃
分子量:816.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ARCA 構造式

CAS 番号: 400806-46-4

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

ARCA-capped mRNA serves as the reference for translational efficiency and total protein expression in human immature dendritic cells, with a total protein expression of 1.00 and translational efficiency of 1.00^[1].
ARCA enables proper cotranscriptional capping of in vitro transcribed mRNA by preventing reverse cap orientation, thereby supporting mRNA translation efficiency and stability^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 400806-46-4
分子量 816.46
分子式 C₂₂H₃₁N₁₀O₁₈P₃
SMILES

O=C1C([N+](C)=CN2[C@H]3[C@H](O)[C@H](OC)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)(O)=O)(O)=O)([O-])=O)O3)=C2N=C(N)N1
別名

Anti-Reverse cap analog; m2 7,3′O GpppG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kowalska J, et al. Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes. Nucleic acids research. 2014;42(16):10245-64. [Content Brief]

[2]. Bednarczyk M, et al. Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. ACS chemical biology. 2022 Jun 17;17(6):1460-1471.

[3]. Litvinova V R, et al. mRNA vaccine platform: mRNA production and delivery[J]. Russian Journal of Bioorganic Chemistry, 2023, 49(2): 220-235.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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純度とドキュメンテーション
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ARCA

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示