Azamethiphos
Based on 1 Customer Validation
Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.10%
- CAS 番号: 35575-96-3
- 分子式: C9H10ClN2O5PS
- 分子量:324.68
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
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AChE |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:stage I larvae (mean carapace length 2.3 mm)[1]
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Dosage:1, 10, 100, 1000 μg/L
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Administration:aqueous bath; 1 hour
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Result:Caused dose-dependent mortality and immobility.
Reached a 1h-LC50 of 43.1 μg/L.
Reached a 1h-EC50 (mortality + immobility) of 15.5 μg/L.
Resulted in immobilised larvae typically not recovering by 24 h post-exposure and dying.
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Animal Model:stage II larvae (mean carapace length 3.3 mm)[1]
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Dosage:1, 10, 100, 1000 μg/L
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Administration:aqueous bath; 1 hour
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Result:Caused dose-dependent mortality and immobility.
Reached a 1h-LC50 of 20.5 μg/L.
Reached a 1h-EC50 (mortality + immobility) of 9.2 μg/L.
Resulted in immobilised larvae typically not recovering by 24 h post-exposure and dying.
化学情報
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CAS 番号 35575-96-3
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性状 Solid
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分子量 324.68
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分子式 C9H10ClN2O5PS
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Color White to off-white
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SMILES
O=P(OC)(SCN(C1=NC=C(Cl)C=C1O2)C2=O)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 200 mg/mL (615.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (15.40 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (15.40 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0800 mL | 15.3998 mL | 30.7996 mL | 76.9989 mL |
| 5 mM | 0.6160 mL | 3.0800 mL | 6.1599 mL | 15.3998 mL | |
| 10 mM | 0.3080 mL | 1.5400 mL | 3.0800 mL | 7.6999 mL | |
| 15 mM | 0.2053 mL | 1.0267 mL | 2.0533 mL | 5.1333 mL | |
| 20 mM | 0.1540 mL | 0.7700 mL | 1.5400 mL | 3.8499 mL | |
| 25 mM | 0.1232 mL | 0.6160 mL | 1.2320 mL | 3.0800 mL | |
| 30 mM | 0.1027 mL | 0.5133 mL | 1.0267 mL | 2.5666 mL | |
| 40 mM | 0.0770 mL | 0.3850 mL | 0.7700 mL | 1.9250 mL | |
| 50 mM | 0.0616 mL | 0.3080 mL | 0.6160 mL | 1.5400 mL | |
| 60 mM | 0.0513 mL | 0.2567 mL | 0.5133 mL | 1.2833 mL | |
| 80 mM | 0.0385 mL | 0.1925 mL | 0.3850 mL | 0.9625 mL | |
| 100 mM | 0.0308 mL | 0.1540 mL | 0.3080 mL | 0.7700 mL |
Azamethiphos 関連分類
HY-114899 関連分類
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