C215
Based on 1 Customer Validation
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.63%
- CAS 番号: 912780-51-9
- 分子式: C17H17Cl2N3
- 分子量:334.24
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 912780-51-9
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性状 Solid
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分子量 334.24
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分子式 C17H17Cl2N3
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Color White to off-white
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SMILES
CCCN1C2=CC=C(NCC3=CC=C(Cl)C=C3Cl)C=C2N=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 62.5 mg/mL (186.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Drug Screening technologies
Drug screening technologies are experimental and computational strategies used to identify small molecules or chemical probes that modulate a defined molecular target, signaling pathway, cellular phenotype, disease model, or patient-derived response profile. High-throughput screening tests many compounds in miniaturized assay formats, while quantitative high-throughput screening tests compounds across concentration ranges so that potency and efficacy can be inferred from concentration-response behavior rather than from a single-point signal. The core biological function of a drug-screening strategy is to connect compound exposure with measurable pathway activity, target modulation, cell-state change, viability, cytotoxicity, morphology, or disease-relevant phenotype. Assay performance must be evaluated before screening because hit identification depends on the separation between positive and negative controls, control variability, plate effects, outliers, and the statistical framework
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9919 mL | 14.9593 mL | 29.9186 mL | 74.7966 mL |
| 5 mM | 0.5984 mL | 2.9919 mL | 5.9837 mL | 14.9593 mL | |
| 10 mM | 0.2992 mL | 1.4959 mL | 2.9919 mL | 7.4797 mL | |
| 15 mM | 0.1995 mL | 0.9973 mL | 1.9946 mL | 4.9864 mL | |
| 20 mM | 0.1496 mL | 0.7480 mL | 1.4959 mL | 3.7398 mL | |
| 25 mM | 0.1197 mL | 0.5984 mL | 1.1967 mL | 2.9919 mL | |
| 30 mM | 0.0997 mL | 0.4986 mL | 0.9973 mL | 2.4932 mL | |
| 40 mM | 0.0748 mL | 0.3740 mL | 0.7480 mL | 1.8699 mL | |
| 50 mM | 0.0598 mL | 0.2992 mL | 0.5984 mL | 1.4959 mL | |
| 60 mM | 0.0499 mL | 0.2493 mL | 0.4986 mL | 1.2466 mL | |
| 80 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9350 mL | |
| 100 mM | 0.0299 mL | 0.1496 mL | 0.2992 mL | 0.7480 mL |
C215 関連分類
HY-124814 関連分類
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