CCG 224061
CCG 224061 is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with a IC50 of 0.066 μM. CCG 224061 inhibits GRK activity in cardiomyocytes. CCG 224061 is applicable to research related to heart disease, heart failure, myocardial hypertrophy and hypertension.
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- CAS 番号: 2055990-82-2
- 分子式: C19H20FN3O
- 分子量:325.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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GRK2 0.066 μM (IC50) |
CCG 224061 (E18) potently and selectively inhibits GRK2 with an IC50 of 0.07 μM, while it shows weak inhibitory effects on GRK5 (IC50 12.8 μM) and GRK1 (IC50 65.7 μM)[1].
CCG 224061 (5 min) potently inhibits GRK2 (IC50 = 0.066 μM) and exhibits activity against GRK1 (IC50 = 6.4 μM), GRK5 (IC50 = 1.3 μM), PKA (IC50 = 3.1 μM) and ROCK1 (100% inhibition at 10 μM) in in vitro purified kinase assays[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC0-∞ |
|---|---|---|---|
| Mice[2] | 10 mg/kg | i.p. | 731 ng·h/mL |
化学情報
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CAS 番号 2055990-82-2
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分子量 325.39
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分子式 C19H20FN3O
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SMILES
C(OC=1C=C2C(=CC1)NN=C2)[C@H]3[C@@H](CCNC3)C4=CC=C(F)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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