country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-152074

Copy Link Print Information

CD73-IN-14

D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC₅₀ value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8⁺ cells and shows anti-tumor activity. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2407356-67-4
分子式: C₂₆H₂₆ClN₇O₉
分子量:615.98

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

CD73-IN-14 構造式

CAS 番号: 2407356-67-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC₅₀ value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8⁺ cells and shows anti-tumor activity^[1]. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

C₅₀: 0.17 nM (CD73)^[1]

体内実験

CD73-IN-14 (10, 25, 50 mg/kg; p.o.; twice-a-day for 20 days) shows anti-tumor activity in mouse^[1].br/> Pharmacokinetic Parameters of CD73-IN-14 in rats^[1].

PO Dose (mg/kg)	AUC_{0-24 h} (ng*hr/mL)	C_max(nM)	T_max(hr)
50	580	74	0.8
200	6094	1800	0.8
500	18500	11000	0.3

rats, 50, 200, 500 mg/kg p.o.^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (EG7 model)^[1]
Dosage:

10, 25, 50 mg/kg
Administration:

P.o.; twice a day for 20 days
Result:

Increased tumor-infiltrating CD8+ cells and decreased the tumor volume in a dose dependet manner.

化学情報

CAS 番号 2407356-67-4
分子量 615.98
分子式 C₂₆H₂₆ClN₇O₉
SMILES

ClC1=NC2=C(N=CN2[C@H]3[C@@H]([C@@](C#C)([C@H](O3)COC(CC4=CC=C(C=C4)N5C(NCCC5)=O)(C(O)=O)C(O)=O)O)O)C(N)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (282 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li J, et al. Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity. J Med Chem. 2022 Dec 18. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ