CP-447697
Based on 1 Customer Validation
CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.70%
- CAS 番号: 1092847-21-6
- 分子式: C29H26ClF2N3O2S
- 分子量:554.05
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 31 nM (C5a receptor)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
250 nM
Compound: 2, CP-447697
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Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA
Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA
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[PMID: 18809326] |
| U-937 | IC50 |
31 nM
Compound: 2, CP-447697
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Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells
Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells
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[PMID: 18809326] |
化学情報
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CAS 番号 1092847-21-6
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性状 Solid
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分子量 554.05
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分子式 C29H26ClF2N3O2S
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Color White to off-white
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SMILES
ClC(C=C1)=CC=C1CCN(C(C2=CSC3=C2C=CC=C3)=O)C4CCN(C(NC5=CC=C(F)C=C5F)=O)CC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 125 mg/mL (225.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8049 mL | 9.0245 mL | 18.0489 mL | 45.1223 mL |
| 5 mM | 0.3610 mL | 1.8049 mL | 3.6098 mL | 9.0245 mL | |
| 10 mM | 0.1805 mL | 0.9024 mL | 1.8049 mL | 4.5122 mL | |
| 15 mM | 0.1203 mL | 0.6016 mL | 1.2033 mL | 3.0082 mL | |
| 20 mM | 0.0902 mL | 0.4512 mL | 0.9024 mL | 2.2561 mL | |
| 25 mM | 0.0722 mL | 0.3610 mL | 0.7220 mL | 1.8049 mL | |
| 30 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.5041 mL | |
| 40 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1281 mL | |
| 50 mM | 0.0361 mL | 0.1805 mL | 0.3610 mL | 0.9024 mL | |
| 60 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.7520 mL | |
| 80 mM | 0.0226 mL | 0.1128 mL | 0.2256 mL | 0.5640 mL | |
| 100 mM | 0.0180 mL | 0.0902 mL | 0.1805 mL | 0.4512 mL |
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