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製品番号: HY-P10812A

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CP61 acetate

Name: CP61 acetate
Brand: MedChemExpress
SKU: HY-P10812A
Price: 130.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

CP61 acetate is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH (HY-113355) binding, disrupting the NADH-dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation. CP61 acetate can be used in breast cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 98.92%
分子式: C₅₀H₇₃N₁₃O₁₂S·xC₂H₄O₂
分子量:1080.26 (free base)

保管条件:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

CP61 acetate 構造式

容量

価格（税別）

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Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

CtBP1

CtBP2

体外実験

Anti-cancerCell Cycle RegulationCarbohydrate MetabolismOthers

Anti-cancer

Cell Cycle Regulation

CP61 acetate introduces a cysteine by mutating its own SGW sequence to CGW and is conjugated via a disulfide bond to the N-terminally Cys-modified HIV TAT cell-penetrating peptide (GRKKRRQRRRPPQ), thereby achieving intracellular delivery of the cyclic peptide. The resulting CP61 acetate-TAT retains CFP-CtBP1 in the cytoplasm of COS-7 cells without altering total CtBP1/CtBP2 protein levels; it dose-dependently increases the proportion of micronuclei in MCF-7 cells, raises the fraction of abnormal mitosis and prolongs mitotic duration, and inhibits MCF-7 cell proliferation, and this effect is reproducible in ER-negative highly metastatic MDA-MB-231 cells^[1].

Carbohydrate Metabolism

Cell Cycle Regulation

Anti-cancer

CP61 (50 μM; microinjection) acetate selectively increases abnormal mitosis and prolongs mitotic duration in highly glycolytic MCF-7 cells, but has no such effect in MDA-MB-453 cells with lower glycolysis^[1].

Others

CP61 acetate inhibits CtBP2 homodimerization in ELISA assays, IC₅₀ = 19 μM^[1].
CP61 acetate dose-dependently disrupts the GST-CtBP1/His-CtBP1 complex in the presence of 10 μM NADH^[1].
CP61 acetate allosterically and dose-dependently reduces the CtBP1-NADH FRET signal (Trp 285 nm, NADH 425 nm), and the maximal FRET is suppressed under saturating NADH, suggesting that it does not occupy the NADH pocket^[1].
CP61 acetate shows no inhibitory effect on other Rossmann fold-containing NAD⁺/NADH-dependent dehydrogenases at concentrations up to 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

性状 Solid
分子量 1080.26 (free base)
分子式 C₅₀H₇₃N₁₃O₁₂S·xC₂H₄O₂
Color White to off-white
SMILES

O=C(NCC(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@H]3CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)NC3=O.CC(O)=O.[x]
配列

cyclo(Ser-Gly-Trp-Thr-Val-Val-Arg-Met-Tyr)
シーケンスの短縮

cyclo(SGWTVVRMY)
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
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Animal Weight (Per Animal) Animal Weight (Per Animal)
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
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参考文献

[1]. Birts CN, et al. A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells. Chemical science. 2013 Aug 01;4(8):3046-3057. [Content Brief]

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100 mg

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