シクロペントラート 塩酸塩
Based on 1 Customer Validation
Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.54%
- CAS 番号: 5870-29-1
- 分子式: C17H26ClNO3
- 分子量:327.85
-
保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide (OP) poisoning model)[3]
-
Dosage:20 mg/kg (Ophthalmic cyclopentolate)
-
Administration:i.p.
-
Result:Survival in rats pretreated with ophthalmic cyclopentolate (20 mg/kg) is 90%.
化学情報
-
CAS 番号 5870-29-1
-
性状 Solid
-
分子量 327.85
-
分子式 C17H26ClNO3
-
Color White to off-white
-
SMILES
O=C(OCCN(C)C)C(C1(O)CCCC1)C2=CC=CC=C2.[H]Cl
-
別名
Cyclopentolate hydrochloride; DL-Cyclopentolate hydrochloride
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (762.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (305.02 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (305.02 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
-
データシート (284 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928. [Content Brief]
[2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373. [Content Brief]
[3]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.0502 mL | 15.2509 mL | 30.5018 mL | 76.2544 mL |
| 5 mM | 0.6100 mL | 3.0502 mL | 6.1004 mL | 15.2509 mL | |
| 10 mM | 0.3050 mL | 1.5251 mL | 3.0502 mL | 7.6254 mL | |
| 15 mM | 0.2033 mL | 1.0167 mL | 2.0335 mL | 5.0836 mL | |
| 20 mM | 0.1525 mL | 0.7625 mL | 1.5251 mL | 3.8127 mL | |
| 25 mM | 0.1220 mL | 0.6100 mL | 1.2201 mL | 3.0502 mL | |
| 30 mM | 0.1017 mL | 0.5084 mL | 1.0167 mL | 2.5418 mL | |
| 40 mM | 0.0763 mL | 0.3813 mL | 0.7625 mL | 1.9064 mL | |
| 50 mM | 0.0610 mL | 0.3050 mL | 0.6100 mL | 1.5251 mL | |
| 60 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2709 mL | |
| 80 mM | 0.0381 mL | 0.1906 mL | 0.3813 mL | 0.9532 mL | |
| 100 mM | 0.0305 mL | 0.1525 mL | 0.3050 mL | 0.7625 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclopentolate hydrochloride 関連分類
HY-B1621A 関連分類
Powered by Bioz